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Title: Physiological and pathophysiological roles of transient receptor potential channels in microglia-related CNS inflammatory diseases
Authors: Shirakawa, Hisashi
Kaneko, Shuji
Author's alias: 白川, 久志
金子, 周司
Keywords: microglia
transient receptor potential (TRP) channel
central nervous system (CNS) inflammation
Ca²⁺ signaling
reactive oxygen species
Issue Date: 1-Aug-2018
Publisher: Pharmaceutical Society of Japan
Journal title: Biological and Pharmaceutical Bulletin
Volume: 41
Issue: 8
Start page: 1152
End page: 1157
Abstract: Central nervous system (CNS) inflammation is a potential therapeutic target for neurodegenerative diseases. In recent years, a number of studies have focused on the links between neurodegenerative diseases and CNS glial cells, especially microglia. Microglia are the main resident immune cells in the CNS and represent approximately 10–15% of all CNS cells. Microglia play an important role in maintaining brain homeostasis at rest by surveying the environment, and engulfing apoptotic cells and debris in the healthy brain. However, under certain pathological conditions, microglia can generate neurotoxic factors, such as pro-inflammatory cytokines and molecules like nitric oxide (NO), which lead to CNS inflammatory diseases. In this review, we discuss the evidence that regulation of microglial ion channels may modulate CNS inflammation and subsequent tissue damage in neurological disorders. In particular, we discuss the role of transient receptor potential (TRP) channels in microglia in both acute and chronic inflammatory conditions, and describe the physiological and pathophysiological roles of TRP channels in CNS inflammatory pathways. Additionally, we describe the benefits of stimulation/inhibition of TRP channels in animal models of microglia-related CNS inflammatory diseases.
Rights: © 2018 The Pharmaceutical Society of Japan. 許諾条件に基づいて掲載しています。
DOI(Published Version): 10.1248/bpb.b18-00319
PubMed ID: 30068863
Appears in Collections:Journal Articles

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