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j.brainres.2018.09.031.pdf | 1.41 MB | Adobe PDF | 見る/開く |
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DCフィールド | 値 | 言語 |
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dc.contributor.author | Andoh, Chihiro | en |
dc.contributor.author | Nishitani, Naoya | en |
dc.contributor.author | Hashimoto, Emina | en |
dc.contributor.author | Nagai, Yuma | en |
dc.contributor.author | Takao, Keizo | en |
dc.contributor.author | Miyakawa, Tsuyoshi | en |
dc.contributor.author | Nakagawa, Takayuki | en |
dc.contributor.author | Mori, Yasuo | en |
dc.contributor.author | Nagayasu, Kazuki | en |
dc.contributor.author | Shirakawa, Hisashi | en |
dc.contributor.author | Kaneko, Shuji | en |
dc.contributor.alternative | 安藤 千紘 | ja |
dc.contributor.alternative | 西谷 直也 | ja |
dc.contributor.alternative | 中川, 貴之 | ja |
dc.contributor.alternative | 森, 泰生 | ja |
dc.contributor.alternative | 永安, 一樹 | ja |
dc.contributor.alternative | 白川, 久志 | ja |
dc.contributor.alternative | 金子, 周司 | ja |
dc.date.accessioned | 2019-05-27T05:38:52Z | - |
dc.date.available | 2019-05-27T05:38:52Z | - |
dc.date.issued | 2019-02-01 | - |
dc.identifier.issn | 0006-8993 | - |
dc.identifier.issn | 1872-6240 | - |
dc.identifier.uri | http://hdl.handle.net/2433/241623 | - |
dc.description.abstract | Transient receptor potential melastatin 2 (TRPM2) is a Ca²⁺-permeable, nonselective cation channel and a member of the TRP channel superfamily that acts as a sensor of intracellular redox states. TRPM2 is widely distributed in many tissues and highly expressed in the brain, but the physiological roles of TRPM2 in the central nervous system remain unclear. In this study, TRPM2-deficient mice were examined in a series of behavioral tests. TRPM2-deficient mice did not significantly differ from wild-type littermates in muscle strength, light/dark transition test, rotarod, elevated plus maze, social interaction, prepulse inhibition, Y-maze, forced swim test, cued and contextual fear conditioning, and tail suspension test. In the Barnes circular maze, TRPM2-deficient mice learned the fixed escape box position at similar extent to wild-type littermates, suggesting normal reference memory. However, performance of the first reversal trial and probe test were significantly impaired in TRPM2-deficient mice. In the T-maze delayed alternation task, TRPM2 deficiency significantly reduced choice accuracy. These results indicate that TRPM2-deficient mice shows behavioral inflexibility. Meanwhile, social avoidance induced by repeated social defeat stress was significantly attenuated in TRPM2-deficient mice, suggesting that TRPM2 deficiency confers stress resiliency. Our findings indicate that TRPM2 plays an essential role in maintaining behavioral flexibility but it increases susceptibility to stress. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. | en |
dc.rights | The full-text file will be made open to the public on 1 February 2020 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.subject | TRPM2 | en |
dc.subject | Stress resiliency | en |
dc.subject | Behavioral inflexibility | en |
dc.title | TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA10859384 | - |
dc.identifier.jtitle | Brain Research Reviews | en |
dc.identifier.volume | 1704 | - |
dc.identifier.spage | 68 | - |
dc.identifier.epage | 77 | - |
dc.relation.doi | 10.1016/j.brainres.2018.09.031 | - |
dc.textversion | author | - |
dc.address | Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University | en |
dc.address | Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University | en |
dc.address | Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University | en |
dc.address | Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University | en |
dc.address | Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki・Life Science Research Center, University of Toyama | en |
dc.address | Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki・Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University | en |
dc.address | Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital | en |
dc.address | Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University | en |
dc.address | Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University | en |
dc.address | Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University | en |
dc.address | Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University | en |
dc.identifier.pmid | 30273551 | - |
dcterms.accessRights | open access | - |
datacite.date.available | 2020-02-01 | - |
datacite.awardNumber | 16K15125 | - |
datacite.awardNumber | 17K19486 | - |
datacite.awardNumber | 17H04008 | - |
datacite.awardNumber | 16H05091 | - |
dc.identifier.pissn | 0165-0173 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
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