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Title: Gold(I)-Catalyzed Oxidative Cascade Cyclization of 1,4-Diyn-3-ones for the Construction of Tropone-Fused Furan Scaffolds
Authors: Hamada, Naoka
Yamaguchi, Ayuta
Inuki, Shinsuke  kyouindb  KAKEN_id  orcid (unconfirmed)
Oishi, Shinya
Ohno, Hiroaki  kyouindb  KAKEN_id  orcid (unconfirmed)
Author's alias: 山口, 亞由太
井貫, 晋輔
大石, 真也
大野, 浩章
Issue Date: 3-Aug-2018
Publisher: American Chemical Society
Journal title: Organic Letters
Volume: 20
Issue: 15
Start page: 4401
End page: 4405
Abstract: Gold(I)-catalyzed cascade cyclization of 1, 4-diyn-3-ones with a pyridine N-oxide enabled direct construction of a benzo[6, 7]cyclohepta[1, 2-b]furan scaffold with the formation of four bonds. This reaction would proceed through oxidative cyclization, alkynyl migration, and 5-endo-dig type cyclization. Synthesis of benzotropone-fused naphtho[1, 2-b]furans through a two-step sequence, including epoxidation and In(OTf)₃-catalyzed intramolecular carbon–carbon bond formation, is also presented.
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in 'Organic Letters', copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
The full-text file will be made open to the public on 23 July 2019 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1021/acs.orglett.8b01524
PubMed ID: 30036068
Appears in Collections:Journal Articles

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