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s10570-018-2027-5.pdf | 5.07 MB | Adobe PDF | 見る/開く |
タイトル: | Methylcelluloses end-functionalized with peptides as thermoresponsive supramolecular hydrogelators |
著者: | Suhara, Ryo Yamagami, Mao Kamitakahara, Hiroshi https://orcid.org/0000-0002-0130-1919 (unconfirmed) Yoshinaga, Arata https://orcid.org/0000-0002-2935-3067 (unconfirmed) Tanaka, Yoshimasa Takano, Toshiyuki |
著者名の別形: | 上髙原, 浩 |
キーワード: | Methylcellulose Peptide End-functionalization Thermoresponsive supramolecular hydrogel |
発行日: | Jan-2019 |
出版者: | Springer Nature |
誌名: | Cellulose |
巻: | 26 |
号: | 1 |
開始ページ: | 355 |
終了ページ: | 382 |
抄録: | This paper describes the synthesis of methylcelluloses end-functionalized with peptides and an investigation into their functions. We found that aqueous solutions of methylcellulose end-functionalized not only with carbohydrates but also with peptide segments, such as di(arginine) and di(glutamic acid), behave as thermoresponsive supramolecular hydrogelators at human-body temperature. The slow drug release from thermoresponsive hydrogels of methylcelluloses end-functionalized with peptides is attributed to ionic interactions between model drugs and peptide segments in these hydrogels. Reactions of methylated cellobiose with di(arginine) and di(glutamic acid) were used to determine optimum reaction conditions for the synthesis of methylcelluloses end-functionalized with these peptide residues). The surface activities, zeta potentials, thermal properties, hydrogelation behavior, and cytotoxicities of these peptide-functionalized methylcelluloses are also discussed. |
著作権等: | This is a post-peer-review, pre-copyedit version of an article published in Cellulose. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10570-018-2027-5. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/242287 |
DOI(出版社版): | 10.1007/s10570-018-2027-5 |
出現コレクション: | 学術雑誌掲載論文等 |
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