|Title:||Biological factor related to Asian sand dust particles contributes to the exacerbation of asthma|
|Authors:||Honda, Akiko https://orcid.org/0000-0002-7358-4372 (unconfirmed)|
Ueda, Kayo https://orcid.org/0000-0002-2104-1384 (unconfirmed)
|Author's alias:||本田, 晶子|
|Keywords:||Asian sand dust particles|
bone‐marrow‐derived antigen presenting cells
|Journal title:||Journal of Applied Toxicology|
|Abstract:||Epidemiologic studies have revealed that Asian sand dust particles (ASDs) can affect respiratory and immune health represented by asthma. Factors responsible for the exacerbation of asthma remain unclear. The fungus Bjerkandera adusta (B.ad) and polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) have been identified in ASDs collected from the atmosphere when an ASD event occurred. We investigated the effects of B.ad and BaP related to ASDs on respiratory and immune systems. Bone marrow‐derived antigen‐presenting cells (APCs) and splenocytes from atopic prone NC/Nga mice and human airway epithelial cells were exposed to the B.ad or to BaP in the presence and absence of heated‐ASDs (H‐ASDs). B.ad and BaP in both the presence and absence of H‐ASDs increased the expression of cell surface molecules on APCs. H‐ASDs alone slightly activated APCs. The expressions induced by B.ad were higher than those induced by BaP in the presence and absence of H‐ASDs. There were no remarkable effects on the activation of splenocytes or the proinflammatory responses in airway epithelial cells. These results suggest that B.ad rather than BaP contributes to the exacerbation of asthma regardless of the presence or absence of sand particles, particularly by the activation of the immune system via APCs.|
|Rights:||This is the peer reviewed version of the following article: 'Journal of Applied Toxicology' 37(5) 583-590, which has been published in final form at https://doi.org/10.1002/jat.3395. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.|
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|Appears in Collections:||Journal Articles|
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