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Title: Synergic effects of 9,10-phenanthrenequinone and cadmium on pro-inflammatory responses in airway epithelial cells
Authors: Honda, Akiko  kyouindb  KAKEN_id  orcid (unconfirmed)
Chowdhury, Pratiti Home
Ito, Sho
Okano, Hitoshi
Onishi, Toshinori
Kawaryu, Yusuke
Ueda, Kayo  kyouindb  KAKEN_id  orcid (unconfirmed)
Takano, Hirohisa  kyouindb  KAKEN_id
Author's alias: 本田, 晶子
上田, 佳代
高野, 裕久
Keywords: Cadmium
9, 10-Phenanthrenequinone
Synergic effects
Airway inflammation
Issue Date: Jun-2017
Publisher: Elsevier BV
Journal title: Environmental Toxicology and Pharmacology
Volume: 52
Start page: 276
End page: 279
Abstract: We investigated the synergic effects of components of particulate matter with aerodynamic diameters ≤2.5 μm (PM2.5) on airway inflammation. Co-exposure to cadmium (Cd) and 9, 10-phenanthrenequinone (9, 10-PQ) additively/synergistically increased pro-inflammatory responses in airway epithelial cells, whereas co-exposure to Cd and phenanthrene resulted in no acceleration. These results suggest that the combination of metal and a quinone derivative can contribute to the exacerbation of respiratory diseases by PM2.5.
Rights: © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
The full-text file will be made open to the public on 1 June 2018 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1016/j.etap.2017.04.019
Appears in Collections:Journal Articles

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