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dc.contributor.authorSaito, Shigeru
dc.contributor.authorAndo, Kenji
dc.contributor.authorIto, Yoshiaki
dc.contributor.authorTobaru, Tetsuya
dc.contributor.authorYajima, Junji
dc.contributor.authorKimura, Takeshi
dc.contributor.authorKadota, Kazushige
dc.contributor.alternative木村, 剛
dc.date.accessioned2019-09-17T06:32:20Z-
dc.date.available2019-09-17T06:32:20Z-
dc.date.issued2019-01
dc.identifier.issn1868-4300
dc.identifier.urihttp://hdl.handle.net/2433/244059-
dc.description.abstractPercutaneous coronary intervention (PCI) in coronary artery disease (CAD) with very small vessels remains challenging. The aim of this study is to evaluate the safety and effectiveness of the 2.25-mm diameter Ultimaster sirolimus-eluting stent in the treatment of Japanese patients with CAD due to lesions in very small vessels. The CENTURY JSV study is a prospective, multicentre, single-arm study. Seventy patients with lesions deemed suitable for implantation of a 2.25-mm diameter stent were enrolled at seven hospitals in Japan. Patients underwent clinical follow-up at 1-, 9-month, 1-, and 2-year after the PCI procedure. The primary endpoint was the major adverse cardiac event (MACE), a composite of cardiac death, target vessel myocardial infarction (MI), and clinically driven target lesion revascularization (TLR) free rate at 9-month following the procedure. The MACE-free rate was 97.1%, and the lower limit of the two-sided 95% confidence interval (CI) was 90.1%, which exceeded the threshold of 80% set as the performance goal. Angiographic in-stent and in-segment late loss at 9-month were 0.22 ± 0.31 and − 0.02 ± 0.34 mm, respectively. Between 9 months and 2 years, two additional TLRs occurred. Stent thrombosis, bleeding and vascular complication did not occur throughout 2 years. The 2.25-mm diameter Ultimaster® bioresorbable-polymer sirolimus-eluting stent is safe and effective for treating lesions in very small coronary arteries throughout 2 years after stent implantation.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.rights© The Author(s) 2018 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
dc.subjectDrug-eluting stent
dc.subjectSirolimus
dc.subjectBioresorbable
dc.subjectVery small vessel
dc.titleTwo-year results after coronary stenting of small vessels in Japanese population using 2.25-mm diameter sirolimus-eluting stent with bioresorbable polymer: primary and long-term outcomes of CENTURY JSV study
dc.type.niitypeJournal Article
dc.identifier.jtitleCardiovascular intervention and therapeutics
dc.identifier.volume34
dc.identifier.issue1
dc.identifier.spage25
dc.identifier.epage33
dc.relation.doi10.1007/s12928-018-0511-3
dc.textversionpublisher
dc.addressDepartment of Cardiology and Catheterization Laboratories, Shonan Kamakura General Hospital
dc.addressDivision of Cardiology, Kokura Memorial Hospital
dc.addressDepartment of Cardiology, Saiseikai Yokohama City Eastern Hospital
dc.addressDepartment of Cardiology, Sakakibara Heart Institute
dc.addressDepartment of Cardiovascular Medicine, The Cardiovascular Institute, Tokyo
dc.addressDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
dc.addressDepartment of Cardiology, Kurashiki Central Hospital
dc.identifier.pmid29349686
Appears in Collections:Journal Articles

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