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| File | Description | Size | Format | |
|---|---|---|---|---|
| j.jacbts.2019.06.001.pdf | 2.52 MB | Adobe PDF | View/Open |
| Title: | Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction |
| Authors: | Ide, Yuya Horie, Takahiro    https://orcid.org/0000-0002-6766-750X (unconfirmed)Saito, Naritatsu Watanabe, Shin Otani, Chiharu Miyasaka, Yui Kuwabara, Yasuhide Nishino, Tomohiro Nakao, Tetsushi Nishiga, Masataka Nishi, Hitoo Nakashima, Yasuhiro Nakazeki, Fumiko Koyama, Satoshi Kimura, Masahiro Tsuji, Shuhei Rodriguez, Randolph Ruiz Xu, Sijia Yamasaki, Tomohiro Watanabe, Toshimitsu Yamamoto, Masamichi Yanagita, Motoko https://orcid.org/0000-0002-0339-9008 (unconfirmed)Kimura, Takeshi Kakizuka, Akira Ono, Koh |
| Author's alias: | 井手, 裕也 堀江, 貴裕 齋藤, 成達 渡邉, 真 大谷, 千春 宮阪, 由依 桑原, 康秀 西野, 共達 中尾, 哲史 西賀, 雅隆 西, 仁勇 中島, 康弘 中関, 典子 木村, 昌弘 辻, 修平 山﨑, 智弘 渡邉, 利光 山本, 正道 柳田, 素子 木村, 剛 垣塚, 彰 尾野, 亘 |
| Keywords: | ATP ER stress KUS121 myocardial infarction |
| Issue Date: | Oct-2019 |
| Publisher: | Elsevier BV |
| Journal title: | JACC: Basic to Translational Science |
| Volume: | 4 |
| Issue: | 6 |
| Start page: | 701 |
| End page: | 714 |
| Abstract: | No effective treatment is yet available to reduce infarct size and improve clinical outcomes after acute myocardial infarction by enhancing early reperfusion therapy using primary percutaneous coronary intervention. The study showed that Kyoto University Substance 121 (KUS121) reduced endoplasmic reticulum stress, maintained adenosine triphosphate levels, and ameliorated the infarct size in a murine cardiac ischemia and reperfusion injury model. The study confirmed the cardioprotective effect of KUS121 in a porcine ischemia and reperfusion injury model. These findings confirmed that KUS121 is a promising novel therapeutic agent for myocardial infarction in conjunction with primary percutaneous coronary intervention. |
| Description: | 京都大学発の薬剤「KUS121」が心筋梗塞サイズを縮小することを解明 --再灌流障害を抑制する新規治療法--. 京都大学プレスリリース. 2019-10-30. |
| Rights: | ©2019 THE AUTHORS. PUBLISHED BY ELSEVIER ON BEHALF OF THE AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION. THIS IS AN OPEN ACCESS ARTICLE UNDER THE CC BY-NC-ND LICENSE ( http://creativecommons.o rg/licenses/by-nc-nd/4.0/ ) . |
| URI: | http://hdl.handle.net/2433/244444 |
| DOI(Published Version): | 10.1016/j.jacbts.2019.06.001 |
| PubMed ID: | 31709319 |
| Related Link: | https://www.kyoto-u.ac.jp/ja/research-news/2019-10-30 |
| Appears in Collections: | Journal Articles |
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