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Title: Foxg specifies sensory neurons in the anterior neural plate border of the ascidian embryo
Authors: Liu, Boqi
Satou, Yutaka
Author's alias: 刘, 柏岐
佐藤, ゆたか
Issue Date: 29-Oct-2019
Publisher: Springer Science and Business Media LLC
Journal title: Nature Communications
Volume: 10
Thesis number: 4911
Abstract: Foxg constitutes a regulatory loop with Fgf8 and plays an important role in the development of anterior placodes and the telencephalon in vertebrate embryos. Ascidians, which belong to Tunicata, the sister group of vertebrates, develop a primitive placode-like structure at the anterior boundary of the neural plate, but lack a clear counterpart of the telencephalon. In this animal, Foxg is expressed in larval palps, which are adhesive organs with sensory neurons. Here, we show that Foxg begins to be expressed in two separate rows of cells within the neural plate boundary region under the control of the MAPK pathway to pattern this region. However, Foxg is not expressed in the brain, and we find no evidence that knockdown of Foxg affects brain formation. Our data suggest that recruitment of Fgf to the downstream of Foxg might have been a critical evolutionary event for the telencephalon in the vertebrate lineage.
Description: 大脳の進化的起源に関わる機構をホヤで解明 --ホヤはなぜ大脳をつくれないのか--. 京都大学プレスリリース. 2019-11-12.
Rights: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
DOI(Published Version): 10.1038/s41467-019-12839-6
PubMed ID: 31664020
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