|Title:||Modified nucleobase-specific gene regulation using engineered transcription activator-like effectors|
Imanishi, Miki https://orcid.org/0000-0002-4172-0966 (unconfirmed)
|Author's alias:||今西, 未来|
|Journal title:||Advanced Drug Delivery Reviews|
|Abstract:||Epigenetic modification, as typified by cytosine methylation, is a key aspect of gene regulation that affects many biological processes. However, the biological roles of individual methylated cytosines are poorly understood. Sequence-specific DNA recognition tools can be used to investigate the roles of individual instances of DNA methylation. Transcription activator-like effectors (TALEs), which are DNA-binding proteins, are promising candidate tools with designable sequence specificity and sensitivity to DNA methylation. In this review, we describe the bases of DNA recognition of TALEs, including methylated cytosine recognition, and the applications of TALEs for the study of methylated DNA. In addition, we discuss TALE-based epigenome editing and oxidized methylated cytosine recognition.|
|Rights:||© 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.|
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|Appears in Collections:||Journal Articles|
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