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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| j.addr.2019.08.011.pdf | 624.61 kB | Adobe PDF | 見る/開く |
| タイトル: | Modified nucleobase-specific gene regulation using engineered transcription activator-like effectors |
| 著者: | Tsuji, Shogo Imanishi, Miki    https://orcid.org/0000-0002-4172-0966 (unconfirmed) |
| 著者名の別形: | 今西, 未来 |
| キーワード: | DNA binding DNA methylation Epigenetics Gene manipulation Gene targeting |
| 発行日: | Jul-2019 |
| 出版者: | Elsevier B.V. |
| 誌名: | Advanced Drug Delivery Reviews |
| 巻: | 147 |
| 開始ページ: | 59 |
| 終了ページ: | 65 |
| 抄録: | Epigenetic modification, as typified by cytosine methylation, is a key aspect of gene regulation that affects many biological processes. However, the biological roles of individual methylated cytosines are poorly understood. Sequence-specific DNA recognition tools can be used to investigate the roles of individual instances of DNA methylation. Transcription activator-like effectors (TALEs), which are DNA-binding proteins, are promising candidate tools with designable sequence specificity and sensitivity to DNA methylation. In this review, we describe the bases of DNA recognition of TALEs, including methylated cytosine recognition, and the applications of TALEs for the study of methylated DNA. In addition, we discuss TALE-based epigenome editing and oxidized methylated cytosine recognition. |
| 著作権等: | © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. The full-text file will be made open to the public on 1 July 2020 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
| URI: | http://hdl.handle.net/2433/244858 |
| DOI(出版社版): | 10.1016/j.addr.2019.08.011 |
| PubMed ID: | 31513826 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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