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タイトル: | HIGH STEROL ESTER 1 is a key factor in plant sterol homeostasis |
著者: | Shimada, Takashi L. Shimada, Tomoo Okazaki, Yozo Higashi, Yasuhiro Saito, Kazuki Kuwata, Keiko Oyama, Kaori Kato, Misako Ueda, Haruko Nakano, Akihiko Ueda, Takashi Takano, Yoshitaka https://orcid.org/0000-0003-1427-1322 (unconfirmed) Hara-Nishimura, Ikuko |
著者名の別形: | 島田, 貴士 嶋田, 知生 岡咲, 洋三 東, 弘 斉藤, 和季 桑田, 啓子 小山, 香梨 加藤, 美砂子 上田, 晴子 中野, 明彦 上田, 貴志 高野, 義孝 西村, いくこ |
発行日: | Nov-2019 |
出版者: | Springer Science and Business Media LLC |
誌名: | Nature Plants |
巻: | 5 |
号: | 11 |
開始ページ: | 1154 |
終了ページ: | 1166 |
抄録: | Plants strictly regulate the levels of sterol in their cells, as high sterol levels are toxic. However, how plants achieve sterol homeostasis is not fully understood. We isolated an Arabidopsis thaliana mutant that abundantly accumulated sterol esters in structures of about 1 µm in diameter in leaf cells. We designated the mutant high sterol ester 1 (hise1) and called the structures sterol ester bodies. Here, we show that HISE1, the gene product that is altered in this mutant, functions as a key factor in plant sterol homeostasis on the endoplasmic reticulum (ER) and participates in a fail-safe regulatory system comprising two processes. First, HISE1 downregulates the protein levels of the β-hydroxy β-methylglutaryl-CoA reductases HMGR1 and HMGR2, which are rate-limiting enzymes in the sterol synthesis pathway, resulting in suppression of sterol overproduction. Second, if the first process is not successful, excess sterols are converted to sterol esters by phospholipid sterol acyltransferase1 (PSAT1) on ER microdomains and then segregated in SE bodies. |
記述: | ステロールの過剰集積を防ぐ植物の技を解明 --二段階フェイルセーフ・システム--. 京都大学プレスリリース. 2019-11-15. |
著作権等: | This is the accepted manuscript of the article, which has been published in final form at https://doi.org/10.1038/s41477-019-0537-2. The full-text file will be made open to the public on 11 May 2020 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/245136 |
DOI(出版社版): | 10.1038/s41477-019-0537-2 |
PubMed ID: | 31712757 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2019-11-15 |
出現コレクション: | 学術雑誌掲載論文等 |
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