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Title: Isolated Tricuspid Regurgitation and Long-Term Outcome in Patients With Preserved Ejection Fraction
Authors: Seko, Yuta
Kato, Takao  kyouindb  KAKEN_id  orcid (unconfirmed)
Shiba, Masayuki
Morita, Yusuke
Yamaji, Yuhei
Haruna, Yoshizumi
Nakane, Eisaku
Haruna, Tetsuya
Inoko, Moriaki
Author's alias: 加藤, 貴雄
柴, 昌行
Keywords: Ejection fraction
Tricuspid valve
Issue Date: 10-Dec-2019
Publisher: Japanese Circulation Society
Journal title: Circulation Reports
Volume: 1
Issue: 12
Start page: 617
End page: 622
Abstract: Background:The aim of this study was to evaluate the association of isolated tricuspid regurgitation (TR) with long-term outcome in patients with preserved left ventricular ejection fraction (LVEF). Methods and Results:We retrospectively analyzed 3, 714 patients who had undergone both scheduled transthoracic echocardiography and electrocardiography in 2013 in a hospital-based population, after excluding severe and moderate left-side valvular disease and LVEF <50%. We classified patients into 2 groups: moderate to severe TR (n=53) and no moderate to severe TR (n=3, 661). Next, we generated a propensity score (PS)-matched cohort: the moderate to severe TR group and the no moderate to severe TR group (n=41 in each group). The primary outcome was a composite of all-cause death and major adverse cardiac events. In the moderate to severe TR group, patients were older, and more likely to have higher left atrial volume index and E/e’ than those in the no moderate to severe TR group. In the PS-matched cohort, cumulative 3-year incidence of the primary outcome was 61.5% in the moderate to severe TR group and 24.3% in the no moderate to severe TR group (log-rank P=0.043; hazard ratio, 2.86; 95% CI: 1.37–6.37). Conclusions:Isolated moderate to severe TR is associated with poor clinical outcome in patients with preserved LVEF.
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DOI(Published Version): 10.1253/circrep.CR-19-0112
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