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dc.contributor.author | Dougnon, Godfried | en |
dc.contributor.author | Ito, Michiho | en |
dc.contributor.alternative | 伊藤, 美千穂 | ja |
dc.date.accessioned | 2020-01-21T06:31:15Z | - |
dc.date.available | 2020-01-21T06:31:15Z | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 1340-3443 | - |
dc.identifier.issn | 1861-0293 | - |
dc.identifier.uri | http://hdl.handle.net/2433/245426 | - |
dc.description.abstract | Lantana camara Linn. (Verbenaceae) is used traditionally for its numerous medicinal properties such as antimalarial, antibacterial, anticancer and anti-inflammatory. In the present study, we investigated the chemical composition of essential oil from the leaves of L. camara (LCEO) occurring in the Republic of Benin (West Africa) in comparison with LCEOs from other regions; evaluated its sedative effects in mice via inhalation administration; and identified the compounds responsible for activity. LCEO was extracted by hydrodistillation and chemical analyses of the oil were performed by GC and GC/MS. The oil was dominated by monoterpene hydrocarbons (60.58%) and oxygenated monoterpenes (33.39%), among which sabinene (38.81%) and 1, 8-cineole (28.90%) were the most abundant. LCEO administered via inhalation to mice significantly decreased locomotor activity in a dose-dependent manner, mainly at the doses of 0.0004 and 0.04 mg per 400 μL of triethyl citrate (TEC). The oil was fractionated to give two fractions, which were further investigated, and revealed that both sabinene and 1, 8-cineole were the principal active compounds. The results of the present study indicated that via inhalation administration, LCEO and its main constituents could be considered as promising candidates for the management of dementia, insomnia, attention deficit hyperactivity disorder and other central nervous system-associated diseases. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | en |
dc.rights | This is a post-peer-review, pre-copyedit version of an article published in 'Journal of Natural Medicines’. The final authenticated version is available online at: https://doi.org/10.1007/s11418-019-01358-9. | en |
dc.rights | The full-text file will be made open to the public on 24 August 2020 in accordance with publisher's 'Terms and Conditions for Self-Archiving' | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.subject | Lantana camara essential oil | en |
dc.subject | Vapor inhalation | en |
dc.subject | GC/MS | en |
dc.subject | Sedative effect | en |
dc.subject | Sabinene | en |
dc.subject | 1, 8-Cineole | en |
dc.title | Sedative effects of the essential oil from the leaves of Lantana camara occurring in the Republic of Benin via inhalation in mice | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA12114658 | - |
dc.identifier.jtitle | Journal of Natural Medicines | en |
dc.identifier.volume | 74 | - |
dc.identifier.spage | 159 | - |
dc.identifier.epage | 169 | - |
dc.relation.doi | 10.1007/s11418-019-01358-9 | - |
dc.textversion | author | - |
dc.address | Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyoto University | en |
dc.address | Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyoto University | en |
dc.identifier.pmid | 31446559 | - |
dcterms.accessRights | open access | - |
datacite.date.available | 2020-08-24 | - |
dc.identifier.pissn | 1340-3443 | - |
dc.identifier.eissn | 1861-0293 | - |
出現コレクション: | 学術雑誌掲載論文等 |
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