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Title: Evaluation of Dynamic Tumor-tracking Intensity-modulated Radiotherapy for Locally Advanced Pancreatic Cancer
Authors: Nakamura, Akira
Hiraoka, Masahiro
Itasaka, Satoshi
Nakamura, Mitsuhiro
Akimoto, Mami
Ishihara, Yoshitomo
Mukumoto, Nobutaka  kyouindb  KAKEN_id
Goto, Yoko
Kishi, Takahiro
Yoshimura, Michio  kyouindb  KAKEN_id  orcid (unconfirmed)
Matsuo, Yukinori  kyouindb  KAKEN_id  orcid (unconfirmed)
Yano, Shinsuke
Mizowaki, Takashi  kyouindb  KAKEN_id  orcid (unconfirmed)
Author's alias: 中村, 晶
平岡, 真寛
板坂, 聡
中村, 光宏
秋元, 麻未
石原, 佳知
椋本, 宜学
後藤, 容子
岸, 高宏
吉村, 通央
松尾, 幸憲
矢野, 慎輔
溝脇, 尚志
Keywords: Pancreatic cancer
Issue Date: 20-Nov-2018
Publisher: Springer Nature
Journal title: Scientific Reports
Volume: 8
Thesis number: 17096
Abstract: Intensity-modulated radiotherapy (IMRT) is now regarded as an important treatment option for patients with locally advanced pancreatic cancer (LAPC). To reduce the underlying tumor motions and dosimetric errors during IMRT as well as the burden of respiratory management for patients, we started to apply a new treatment platform of the dynamic tumor dynamic tumor-tracking intensity-modulated radiotherapy (DTT-IMRT) using the gimbaled linac, which can swing IMRT toward the real-time tumor position under patients’ voluntary breathing. Between June 2013 and March 2015, ten patients were treated, and the tumor-tracking accuracy and the practical benefits were evaluated. The mean PTV size in DTT-IMRT was 18% smaller than a conventional ITV-based PTV. The root-mean-squared errors between the predicted and the detected tumor positions were 1.3, 1.2, and 1.5 mm in left-right, anterior-posterior, and cranio-caudal directions, respectively. The mean in-room time was 24.5 min. This high-accuracy of tumor-tracking with reasonable treatment time are promising and beneficial to patients with LAPC.
Rights: © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
DOI(Published Version): 10.1038/s41598-018-35402-7
PubMed ID: 30459454
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