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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| s41598-019-42661-5.pdf | 4.22 MB | Adobe PDF | 見る/開く |
| タイトル: | An innate interaction between IL-18 and the propeptide that inactivates its precursor form |
| 著者: | Tsutsumi, Naotaka Yokota, Ayumi Kimura, Takeshi Kato, Zenichiro Fukao, Toshiyuki Shirakawa, Masahiro   Ohnishi, Hidenori Tochio, Hidehito  https://orcid.org/0000-0003-3843-3330 (unconfirmed) |
| 著者名の別形: | 堤, 尚孝 木村, 豪 加藤, 善一郎 深尾, 敏幸 白川, 昌宏 大西, 秀典 杤尾, 豪人 |
| キーワード: | Interleukins NMR spectroscopy |
| 発行日: | 16-Apr-2019 |
| 出版者: | Springer Nature |
| 誌名: | Scientific Reports |
| 巻: | 9 |
| 論文番号: | 6160 |
| 抄録: | Uncontrolled secretion of mature interleukin (IL)-1β and IL-18 is responsible for severe autoinflammatory or autoimmune disorders and various allergic diseases. Here we report an intramolecular interaction between IL-18 and its propeptide, which is proteolytically removed from its precursor proIL-18 during maturation. The intramolecular interaction was recapitulated intermolecularly using recombinant propeptide. These results suggest the possibility of developing a novel class of peptide-based IL-18 inhibitors that could serve as therapeutic agents for IL-18-related inflammatory diseases. |
| 著作権等: | © The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| URI: | http://hdl.handle.net/2433/250006 |
| DOI(出版社版): | 10.1038/s41598-019-42661-5 |
| PubMed ID: | 30992532 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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