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Title: Polarized Cellular Mechanoresponse System for Maintaining Radial Size in Developing Epithelial Tubes
Authors: Hirashima, Tsuyoshi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-7323-9627 (unconfirmed)
Adachi, Taiji  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-5280-4156 (unconfirmed)
Author's alias: 平島, 剛志
安達, 泰治
Keywords: Epithelial tube
Mechano-response
Quantitative imaging
Tissue polarity
Tissue size control
Vertex model
Mouse
Issue Date: 2-Dec-2019
Publisher: The Company of Biologists
Journal title: Development
Volume: 146
Issue: 23
Thesis number: dev181206
Abstract: Size control in biological tissues involves multicellular communication via mechanical forces during development. Although fundamental cellular behaviours in response to mechanical stimuli underlie size maintenance during morphogenetic processes, the mechanisms underpinning the cellular mechano-response system that maintains size along an axis of a polarized tissue remain elusive. Here, we show how the diameter of an epithelial tube is maintained during murine epididymal development by combining quantitative imaging, mechanical perturbation and mathematical modelling. We found that epithelial cells counteract compressive forces caused by cell division exclusively along the circumferential axis of the tube to produce polarized contractile forces, eventually leading to an oriented cell rearrangement. Moreover, a mathematical model that includes the polarized mechano-responsive regime explains how the diameter of proliferating tubes is maintained. Our findings pave the way for an improved understanding of the cellular response to mechanical forces that involves collective multicellular behaviours for organizing diverse tissue morphologies.
Rights: © 2019. Published by The Company of Biologists Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
URI: http://hdl.handle.net/2433/250045
DOI(Published Version): 10.1242/dev.181206
PubMed ID: 31619390
Appears in Collections:Journal Articles

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