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Title: Night Monkey Hybrids Exhibit De Novo Genomic and Karyotypic Alterations: The First Such Case in Primates
Authors: Hirai, Hirohisa
Hirai, Yuriko
Morimoto, Mayumi
Kaneko, Akihisa
Kamanaka, Yoshiro
Koga, Akihiko  kyouindb  KAKEN_id
Author's alias: 古賀, 章彦
Keywords: interspecies hybridization
chromosome paint analysis
reciprocal translocation
hybridization effect
Issue Date: 1-Apr-2017
Publisher: Oxford University Press (OUP)
Journal title: Genome biology and evolution
Volume: 9
Issue: 4
Start page: 945
End page: 955
Abstract: Using molecular chromosomal analyses, we discovered night monkey hybrids produced in captivity from matings between a female Aotus azarae boliviensis (2n = 50) and a male Aotus lemurinus griseimembra (2n = 53). The parents produced seven offspring in total, including one male and six females-a pattern consistent with Haldane's rule. Chromosomal studies were conducted on four of the hybrid offspring. Two of them showed relatively "simple" mixture karyotypes, including different chromosome numbers (2n = 51, 52), which were formed because of a heteromorphic autosome pair in the father (n = 26, 27). The other two hybrid monkeys exhibited de novo genomic and karyotypic alterations. Detailed analysis of the alterations revealed that one individual carried a mixture karyotype of the two parental species and an X chromosome trisomy (53, XXX). The second individual displayed trisomy of chromosome 18 (52, XX, +18) and a reciprocal translocation between autosomes 21 and 23 (52, XX, +18, t(21;23)). Interestingly, the second monkey exhibited mosaicism among blood cells (mos52, XX, +18[87]/52, XX, +18, t(21;23)[85]), but only a single karyotype (52, XX, +18) in skin fibroblast cells. The X- and 18-trisomies were derived from a doubling of the mother's chromosomes in early embryonic cell division, and the reciprocal translocation likely developed in the bone marrow of the offspring, considering that it was observed only in blood cells. Such occurrence of trisomies in hybrid individuals is a unique finding in placental mammals.
Rights: © The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact
DOI(Published Version): 10.1093/gbe/evx058
PubMed ID: 28369492
Appears in Collections:Journal Articles

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