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Title: Amygdala activity related to perceived social support
Authors: Sato, Wataru
Kochiyama, Takanori
Uono, Shota
Sawada, Reiko
Yoshikawa, Sakiko
Author's alias: 佐藤, 弥
吉川, 左紀子
Issue Date: 19-Feb-2020
Publisher: Springer Nature
Journal title: Scientific Reports
Volume: 10
Thesis number: 2951
Abstract: Perceived social support enhances well-being and prevents stress-related ill-being. A recent structural neuroimaging study reported that the amygdala volume is positively associated with perceived social support. However, it remains unknown how neural activity in this region and functional connectivity (FC) between this and other regions are related to perceived social support. To investigate these issues, resting-state functional magnetic resonance imaging was performed to analyze the fractional amplitude of low-frequency fluctuation (fALFF). Perceived social support was evaluated using the Multidimensional Scale of Perceived Social Support (MSPSS). Lower fALFF values in the bilateral amygdalae were associated with higher MSPSS scores. Additionally, stronger FC between the left amygdala and right orbitofrontal cortex and between the left amygdala and bilateral precuneus were associated with higher MSPSS scores. The present findings suggest that reduced amygdala activity and heightened connectivity between the amygdala and other regions underlie perceived social support and its positive functions.
Rights: © 2020 The Author(s). Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
URI: http://hdl.handle.net/2433/250078
DOI(Published Version): 10.1038/s41598-020-59758-x
PubMed ID: 32076036
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