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Title: Recent Advances in Immunotherapy for Hepatocellular Carcinoma
Authors: Nakano, Shigeharu
Eso, Yuji  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-4426-1491 (unconfirmed)
Okada, Hirokazu
Takai, Atsushi  kyouindb  KAKEN_id
Takahashi, Ken  kyouindb  KAKEN_id
Seno, Hiroshi
Author's alias: 中野, 重治
恵荘, 裕嗣
髙井, 淳
高橋, 健
妹尾, 浩
Keywords: hepatocellular carcinoma
immunotherapy
immune checkpoint inhibitor
PD-1
CTLA-4
combination therapy
Issue Date: 1-Apr-2020
Publisher: MDPI AG
Journal title: Cancers
Volume: 12
Issue: 4
Thesis number: 775
Abstract: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death since most patients are diagnosed at advanced stage and the current systemic treatment options using molecular-targeted drugs remain unsatisfactory. However, the recent success of cancer immunotherapies has revolutionized the landscape of cancer therapy. Since HCC is characterized by metachronous multicentric occurrence, immunotherapies that induce systemic and durable responses could be an appealing treatment option. Despite the suppressive milieu of the liver and tumor immunosurveillance escape mechanisms, clinical studies of checkpoint inhibitors in patients with advanced HCC have yielded promising results. Here, we provide an update on recent advances in HCC immunotherapies. First, we describe the unique tolerogenic properties of hepatic immunity and its interaction with HCC and then review the status of already or nearly available immune checkpoint blockade-based therapies as well as other immunotherapy strategies at the preclinical or clinical trial stage.
Rights: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
URI: http://hdl.handle.net/2433/250362
DOI(Published Version): 10.3390/cancers12040775
PubMed ID: 32218257
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