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タイトル: Optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift
著者: Amita, Hidetoshi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-8809-064X (unconfirmed)
Kim, Hyoung F.
Inoue, Ken-ichi
Takada, Masahiko  KAKEN_id  orcid https://orcid.org/0000-0003-0774-2333 (unconfirmed)
Hikosaka, Okihide
著者名の別形: 網田, 英敏
井上, 謙一
髙田, 昌彦
彦坂, 興秀
キーワード: Basal ganglia
Decision
Neural circuits
発行日: 20-Apr-2020
出版者: Springer Nature
誌名: Nature communication
巻: 11
論文番号: 1876
抄録: In the primate basal ganglia, the caudate tail (CDt) encodes the historical values (good or bad) of visual objects (i.e., stable values), and electrical stimulation of CDt evokes saccadic eye movements. However, it is still unknown how output from CDt conveys stable value signals to govern behavior. Here, we apply a pathway-selective optogenetic manipulation to elucidate how such value information modulates saccades. We express channelrhodopsin-2 in CDt delivered by viral vector injections. Selective optical activation of CDt-derived terminals in the substantia nigra pars reticulata (SNr) inhibits SNr neurons. Notably, these SNr neurons show inhibitory responses to good objects. Furthermore, the optical stimulation causes prolonged excitation of visual-saccadic neurons in the superior colliculus (SC), and induces contralateral saccades. These SC neurons respond more strongly to good than to bad objects in the contralateral hemifield. The present results demonstrate that CDt facilitates saccades toward good objects by serial inhibitory pathways through SNr.
記述: 価値あるものを見つける神経回路機構を解明 --価値情報を眼球運動に変換する仕組み--. 京都大学プレスリリース. 2020-04-23.
How your brain finds the good objects. 京都大学プレスリリース. 2020-09-14.
著作権等: This is a U.S. government work and not under copyright protection in the U.S.; foreigncopyright protection may apply 2020.
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
URI: http://hdl.handle.net/2433/250479
DOI(出版社版): 10.1038/s41467-020-15802-y
PubMed ID: 32312986
関連リンク: https://www.kyoto-u.ac.jp/ja/research-news/2020-04-23
出現コレクション:学術雑誌掲載論文等

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