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Title: Animal Model for Prodromal Parkinson’s Disease
Authors: Taguchi, Tomoyuki
Ikuno, Masashi  kyouindb  KAKEN_id
Yamakado, Hodaka  kyouindb  KAKEN_id
Takahashi, Ryosuke  kyouindb  KAKEN_id
Author's alias: 田口, 智之
生野, 真嗣
山門, 穂高
髙橋, 良輔
Keywords: Parkinson’s disease
animal model
alpha synuclein
Issue Date: 2-Mar-2020
Publisher: MDPI AG
Journal title: International Journal of Molecular Sciences
Volume: 21
Issue: 6
Thesis number: 1961
Abstract: Parkinson’s disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra and subsequent motor symptoms, but various non-motor symptoms (NMS) often precede motor symptoms. Recently, NMS have attracted much attention as a clue for identifying patients in a prodromal stage of PD, which is an excellent point at which to administer disease-modifying therapies (DMTs). These prodromal symptoms include olfactory loss, constipation, and sleep disorders, especially rapid eye movement sleep behavior disorder (RBD), all of which are also important for elucidating the mechanisms of the initiation and progression of the disease. For the development of DMTs, an animal model that reproduces the prodromal stage of PD is also needed. There have been various mammalian models reported, including toxin-based, genetic, and alpha synuclein propagation models. In this article, we review the animal models that exhibit NMS as prodromal symptoms and also discuss an appropriate prodromal model and its importance for the development of DMT of PD.
Rights: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
DOI(Published Version): 10.3390/ijms21061961
PubMed ID: 32183024
Appears in Collections:Journal Articles

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