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タイトル: | Animal Model for Prodromal Parkinson’s Disease |
著者: | Taguchi, Tomoyuki https://orcid.org/0000-0002-8475-2589 (unconfirmed) Ikuno, Masashi Yamakado, Hodaka Takahashi, Ryosuke https://orcid.org/0000-0002-1407-9640 (unconfirmed) |
著者名の別形: | 田口, 智之 生野, 真嗣 山門, 穂高 髙橋, 良輔 |
キーワード: | Parkinson’s disease prodromal animal model alpha synuclein |
発行日: | 2-Mar-2020 |
出版者: | MDPI AG |
誌名: | International Journal of Molecular Sciences |
巻: | 21 |
号: | 6 |
論文番号: | 1961 |
抄録: | Parkinson’s disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra and subsequent motor symptoms, but various non-motor symptoms (NMS) often precede motor symptoms. Recently, NMS have attracted much attention as a clue for identifying patients in a prodromal stage of PD, which is an excellent point at which to administer disease-modifying therapies (DMTs). These prodromal symptoms include olfactory loss, constipation, and sleep disorders, especially rapid eye movement sleep behavior disorder (RBD), all of which are also important for elucidating the mechanisms of the initiation and progression of the disease. For the development of DMTs, an animal model that reproduces the prodromal stage of PD is also needed. There have been various mammalian models reported, including toxin-based, genetic, and alpha synuclein propagation models. In this article, we review the animal models that exhibit NMS as prodromal symptoms and also discuss an appropriate prodromal model and its importance for the development of DMT of PD. |
著作権等: | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
URI: | http://hdl.handle.net/2433/250906 |
DOI(出版社版): | 10.3390/ijms21061961 |
PubMed ID: | 32183024 |
出現コレクション: | 学術雑誌掲載論文等 |
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