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Title: Repressive chromatin modification underpins the long-term expression trend of a perennial flowering gene in nature
Authors: Nishio, Haruki
Buzas, Diana M.
Nagano, Atsushi J.
Iwayama, Koji
Ushio, Masayuki  KAKEN_id  orcid (unconfirmed)
Kudoh, Hiroshi  kyouindb  KAKEN_id  orcid (unconfirmed)
Author's alias: 西尾, 治幾
永野, 惇
岩山, 幸治
潮, 雅之
工藤, 洋
Keywords: Epigenetics
Plant ecology
Plant molecular biology
Issue Date: 1-May-2020
Publisher: Springer Nature
Journal title: Nature Communications
Volume: 11
Thesis number: 2065
Abstract: Natural environments require organisms to possess robust mechanisms allowing responses to seasonal trends. In Arabidopsis halleri, the flowering regulator AhgFLC shows upregulation and downregulation phases along with long-term past temperature, but the underlying machinery remains elusive. Here, we investigate the seasonal dynamics of histone modifications, H3K27me3 and H3K4me3, at AhgFLC in a natural population. Our advanced modelling and transplant experiments reveal that H3K27me3-mediated chromatin regulation at AhgFLC provides two essential properties. One is the ability to respond to the long-term temperature trends via bidirectional interactions between H3K27me3 and H3K4me3; the other is the ratchet-like character of the AhgFLC system, i.e. reversible in the entire perennial life cycle but irreversible during the upregulation phase. Furthermore, we show that the long-term temperature trends are locally indexed at AhgFLC in the form of histone modifications. Our study provides a more comprehensive understanding of H3K27me3 function at AhgFLC in a complex natural environment.
Description: 植物が春の「暖かさ」を感じて「寒さ」を無視して花を咲かせるしくみを解明. 京都大学プレスリリース. 2020-05-29.
Rights: © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
DOI(Published Version): 10.1038/s41467-020-15896-4
PubMed ID: 32358518
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