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dc.contributor.author | Nagaoka, So I. | en |
dc.contributor.author | Nakaki, Fumio | en |
dc.contributor.author | Miyauchi, Hidetaka | en |
dc.contributor.author | Nosaka, Yoshiaki | en |
dc.contributor.author | Ohta, Hiroshi | en |
dc.contributor.author | Yabuta, Yukihiro | en |
dc.contributor.author | Kurimoto, Kazuki | en |
dc.contributor.author | Hayashi, Katsuhiko | en |
dc.contributor.author | Nakamura, Tomonori | en |
dc.contributor.author | Yamamoto, Takuya | en |
dc.contributor.author | Saitou, Mitinori | en |
dc.contributor.alternative | 長岡, 創 | ja |
dc.contributor.alternative | 中木, 文雄 | ja |
dc.contributor.alternative | 宮内, 英孝 | ja |
dc.contributor.alternative | 野阪, 善昭 | ja |
dc.contributor.alternative | 大田, 浩 | ja |
dc.contributor.alternative | 薮田, 幸宏 | ja |
dc.contributor.alternative | 栗本, 一基 | ja |
dc.contributor.alternative | 林, 克彦 | ja |
dc.contributor.alternative | 中村, 友紀 | ja |
dc.contributor.alternative | 山本, 拓也 | ja |
dc.contributor.alternative | 斎藤, 通紀 | ja |
dc.date.accessioned | 2020-06-09T04:15:49Z | - |
dc.date.available | 2020-06-09T04:15:49Z | - |
dc.date.issued | 2020-03-06 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.issn | 1095-9203 | - |
dc.identifier.uri | http://hdl.handle.net/2433/251201 | - |
dc.description | 生殖細胞が卵母細胞へと分化する仕組みを解明. 京都大学プレスリリース. 2020-02-14. | ja |
dc.description.abstract | Mammalian sexual reproduction relies on the dichotomy of male and female germ cell development. However, the underlying mechanisms remain unclear. Here, we show that ZGLP1, a conserved transcriptional regulator with GATA-like zinc fingers, determines the oogenic fate in mice. ZGLP1 acts downstream of bone morphogenetic protein (BMP), but not retinoic acid (RA), and is essential for the oogenic program and meiotic entry. ZGLP1 overexpression induces differentiation of in vitro primordial germ cell-like cells (PGCLCs) into fetal oocytes by activating the oogenic programs repressed by Polycomb activities, whereas RA signaling contributes to the oogenic program maturation and PGC program repression. Our findings elucidate the mechanism for mammalian oogenic fate determination, providing a foundation for promoting in vitro gametogenesis and reproductive medicine. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Association for the Advancement of Science (AAAS) | en |
dc.rights | This is the author's version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in 'Science' on Vol 367, Issue 6482, 06 March 2020, DOI: 10.1126/science.aaw4115. | en |
dc.rights | The full-text file will be made open to the public on 06 September 2020 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.title | ZGLP1 is a determinant for the oogenic fate in mice | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Science | en |
dc.identifier.volume | 367 | - |
dc.identifier.issue | 6482 | - |
dc.relation.doi | 10.1126/science.aaw4115 | - |
dc.textversion | author | - |
dc.identifier.artnum | eaaw4115 | - |
dc.identifier.pmid | 32054698 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/ja/research-news/2020-02-14 | - |
dcterms.accessRights | open access | - |
datacite.date.available | 2020-09-06 | - |
datacite.awardNumber | 17H06098 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
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