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j.neures.2016.04.007.pdf | 201.67 kB | Adobe PDF | 見る/開く |
タイトル: | Biological mechanisms underlying evolutionary origins of psychotic and mood disorders |
著者: | Goto, Yukiori Lee, Young-A Yamaguchi, Yoshie Jas, Emanuel |
著者名の別形: | 後藤, 幸織 山口, 佳恵 |
キーワード: | Psychiatric disorder Monoamine Social hierarchy Maternal care Epigenetic Neurodevelopment Homophily Symbiosis |
発行日: | Oct-2016 |
出版者: | Elsevier BV |
誌名: | Neuroscience Research |
巻: | 111 |
開始ページ: | 13 |
終了ページ: | 24 |
抄録: | Psychotic and mood disorders are brain dysfunctions that are caused by gene environment interactions. Although these disorders are disadvantageous and involve behavioral phenotypes that decrease the reproductive success of afflicted individuals in the modern human society, the prevalence of these disorders have remained constant in the population. Here, we propose several biological mechanisms by which the genes associated with psychotic and mood disorders could be selected for in specific environmental conditions that provide evolutionary bases for explanations of when, why, and where these disorders emerged and have been maintained in humans. We discuss the evolutionary origins of psychotic and mood disorders with specific focuses on the roles of dopamine and serotonin in the conditions of social competitiveness/hierarchy and maternal care and other potential mechanisms, such as social network homophily and symbiosis. |
著作権等: | © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/252320 |
DOI(出版社版): | 10.1016/j.neures.2016.04.007 |
PubMed ID: | 27230505 |
出現コレクション: | 学術雑誌掲載論文等 |
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