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Title: Distinct Mechanisms of Over-Representation of Landmarks and Rewards in the Hippocampus
Authors: Sato, Masaaki
Mizuta, Kotaro  kyouindb  KAKEN_id
Islam, Tanvir
Kawano, Masako
Sekine, Yukiko
Takekawa, Takashi
Gomez-Dominguez, Daniel
Schmidt, Alexander
Wolf, Fred
Kim, Karam
Yamakawa, Hiroshi
Ohkura, Masamichi
Lee, Min Goo
Fukai, Tomoki
Nakai, Junichi
Hayashi, Yasunori  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-7560-3004 (unconfirmed)
Author's alias: 佐藤, 正晃
水田, 恒太郎
イスラム, タンビル
河野, 真子
関根, 友紀子
竹川, 高志
ゴメスードミンゲス, ダニエル
シュミット, アレキサンダー
ウォルフ, フレッド
キム, カラム
山川, 宏
大倉, 正道
リー, ミン・グー
深井, 朋樹
中井, 淳一
林, 康紀
Keywords: two-photon imaging
G-CaMP7
spatial navigation
cognitive map
spatial learning
memory
Shank
synapses
hippocampal CA1 region
neurodevelopmental disorders
Issue Date: 7-Jul-2020
Publisher: Elsevier BV
Journal title: Cell Reports
Volume: 32
Issue: 1
Thesis number: 107864
Abstract: In the hippocampus, locations associated with salient features are represented by a disproportionately large number of neurons, but the cellular and molecular mechanisms underlying this over-representation remain elusive. Using longitudinal calcium imaging in mice learning to navigate in virtual reality, we find that the over-representation of reward and landmark locations are mediated by persistent and separable subsets of neurons, with distinct time courses of emergence and differing underlying molecular mechanisms. Strikingly, we find that in mice lacking Shank2, an autism spectrum disorder (ASD)-linked gene encoding an excitatory postsynaptic scaffold protein, the learning-induced over-representation of landmarks was absent whereas the over-representation of rewards was substantially increased, as was goal-directed behavior. These findings demonstrate that multiple hippocampal coding processes for unique types of salient features are distinguished by a Shank2-dependent mechanism and suggest that abnormally distorted hippocampal salience mapping may underlie cognitive and behavioral abnormalities in a subset of ASDs.
Description: 脳内地図を細胞レベルで観察 --自閉症関連遺伝子Shank2はランドマーク情報に必須--. 京都大学プレスリリース. 2020-07-09.
Rights: © 2020 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
URI: http://hdl.handle.net/2433/252467
DOI(Published Version): 10.1016/j.celrep.2020.107864
PubMed ID: 32640229
Related Link: https://www.kyoto-u.ac.jp/ja/research-news/2020-07-09-1
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