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Title: Sodium-glucose Co-transporters: Functional Properties and Pharmaceutical Potential
Authors: Sano, Ryuhei
Shinozaki, Yuichi
Ohta, Takeshi
Author's alias: 太田, 毅
Keywords: Antidiabetic drugs
Sodium–glucose cotransporter 1
Sodium–glucose cotransporter 2
Issue Date: Jul-2020
Publisher: Wiley
Journal title: Journal of Diabetes Investigation
Volume: 11
Issue: 4
Start page: 770
End page: 782
Abstract: Glucose is the most abundant monosaccharide, and an essential source of energy for most living cells. Glucose transport across the cell membrane is mediated by two types of transporters: facilitative glucose transporters (gene name: solute carrier 2A) and sodium–glucose cotransporters (SGLTs; gene name: solute carrier 5A). Each transporter has its own substrate specificity, distribution, and regulatory mechanisms. Recently, SGLT1 and SGLT2 have attracted much attention as therapeutic targets for various diseases. This review addresses the basal and functional properties of glucose transporters and SGLTs, and describes the pharmaceutical potential of SGLT1 and SGLT2.
Rights: © 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
DOI(Published Version): 10.1111/jdi.13255
PubMed ID: 32196987
Appears in Collections:Journal Articles

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