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ファイル | 記述 | サイズ | フォーマット | |
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09168451.2020.1747974.pdf | 3.86 MB | Adobe PDF | 見る/開く |
タイトル: | Exploring the binding pocket of quinone/inhibitors in mitochondrial respiratory complex I by chemical biology approaches |
著者: | Murai, Masatoshi https://orcid.org/0000-0001-6601-2854 (unconfirmed) |
著者名の別形: | 村井, 正俊 |
キーワード: | Respiratory complex I mitochondria inhibitor ubiquinone chemical biology |
発行日: | 2-Jul-2020 |
出版者: | Taylor & Francis Group |
誌名: | Bioscience, Biotechnology, and Biochemistry |
巻: | 84 |
開始ページ: | 1322 |
終了ページ: | 1331 |
抄録: | NADH-quinone oxidoreductase (respiratory complex I) is a key player in mitochondrial energy metabolism. The enzyme couples electron transfer from NADH to quinone with the translocation of protons across the membrane, providing a major proton-motive force that drives ATP synthesis. Recently, X-ray crystallography and cryo-electron microscopy provided further insights into the structure and functions of the enzyme. However, little is known about the mechanism of quinone reduction, which is a crucial step in the energy coupling process. A variety of complex I inhibitors targeting the quinone-binding site have been indispensable tools for mechanistic studies on the enzyme. Using biorationally designed inhibitor probes, the author has accumulated a large amount of experimental data characterizing the actions of complex I inhibitors. On the basis of comprehensive interpretations of the data, the author reviews the structural features of the binding pocket of quinone/inhibitors in bovine mitochondrial complex I. |
著作権等: | This is an Accepted Manuscript of an article published by Taylor & Francis Group in 'Bioscience, Biotechnology, and Biochemistry' on 2020, available online: https://www.tandfonline.com/10.1080/09168451.2020.1747974 The full-text file will be made open to the public on 07 Apr 2021 in accordance with publisher's 'Terms and Conditions for Self-Archiving' この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/253575 |
DOI(出版社版): | 10.1080/09168451.2020.1747974 |
PubMed ID: | 32264779 |
出現コレクション: | 学術雑誌掲載論文等 |
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