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タイトル: | Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana |
著者: | Sako, Kaori Futamura, Yushi Shimizu, Takeshi Matsui, Akihiro Hirano, Hiroyuki Kondoh, Yasumitsu Muroi, Makoto Aono, Harumi Tanaka, Maho Honda, Kaori Shimizu, Kenshirou Kawatani, Makoto Nakano, Takeshi https://orcid.org/0000-0002-3188-7770 (unconfirmed) Osada, Hiroyuki Noguchi, Ko Seki, Motoaki |
著者名の別形: | 佐古, 香織 二村, 友史 清水, 猛 松井, 章浩 平野, 弘之 近藤, 恭光 室井, 誠 青野, 晴美 田中, 真帆 本田, 香織 清水, 謙志郎 川谷, 誠 中野, 雄司 長田, 裕之 野口, 航 関, 原明 |
キーワード: | Abiotic Plant sciences Salt |
発行日: | 26-May-2020 |
出版者: | Springer Nature |
誌名: | Scientific Reports |
巻: | 10 |
論文番号: | 8691 |
抄録: | Chemical priming is an attractive and promising approach to improve abiotic stress tolerance in a broad variety of plant species. We screened the RIKEN Natural Products Depository (NPDepo) chemical library and identified a novel compound, FSL0260, enhancing salinity-stress tolerance in Arabidopsis thaliana and rice. Through transcriptome analysis using A. thaliana seedlings, treatment of FSL0260 elevated an alternative respiration pathway in mitochondria that modulates accumulation of reactive oxygen species (ROS). From comparison analysis, we realized that the alternative respiration pathway was induced by treatment of known mitochondrial inhibitors. We confirmed that known inhibitors of mitochondrial complex I, such as rotenone and piericidin A, also enhanced salt-stress tolerance in Arabidopsis. We demonstrated that FSL0260 binds to complex I of the mitochondrial electron transport chain and inhibits its activity, suggesting that inhibition of mitochondrial complex I activates an alternative respiration pathway resulting in reduction of ROS accumulation and enhancement of tolerance to salinity in plants. Furthermore, FSL0260 preferentially inhibited plant mitochondrial complex I rather than a mammalian complex, implying that FSL0260 has a potential to be an agent for improving salt-stress tolerance in agriculture that is low toxicity to humans. |
著作権等: | © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
URI: | http://hdl.handle.net/2433/253686 |
DOI(出版社版): | 10.1038/s41598-020-65614-9 |
PubMed ID: | 32457324 |
出現コレクション: | 学術雑誌掲載論文等 |
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