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タイトル: | Bidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells |
著者: | Kishimoto, Keishi Furukawa Tamura, Kana Luz-Madrigal, Agustin Yamaoka, Akira Matsuoka, Chisa Habu, Masanobu Alev, Cantas https://orcid.org/0000-0002-4879-8782 (unconfirmed) Zorn, Aaron M. Morimoto, Mitsuru |
著者名の別形: | 岸本, 圭史 古川(田村), 可奈 ルズ マドリガル, アウグスティン 山岡, 玲 松岡, 智沙 土生, 正信 アレヴ, ジャンタシュ ゾーン, アーロン 森本, 充 |
キーワード: | Differentiation Organogenesis Regeneration |
発行日: | 27-Aug-2020 |
出版者: | Springer Nature |
誌名: | Nature Communications |
巻: | 11 |
論文番号: | 4159 |
抄録: | The periodic cartilage and smooth muscle structures in mammalian trachea are derived from tracheal mesoderm, and tracheal malformations result in serious respiratory defects in neonates. Here we show that canonical Wnt signaling in mesoderm is critical to confer trachea mesenchymal identity in human and mouse. At the initiation of tracheal development, endoderm begins to express Nkx2.1, and then mesoderm expresses the Tbx4 gene. Loss of β-catenin in fetal mouse mesoderm causes loss of Tbx4+ tracheal mesoderm and tracheal cartilage agenesis. The mesenchymal Tbx4 expression relies on endodermal Wnt activation and Wnt ligand secretion but is independent of known Nkx2.1-mediated respiratory development, suggesting that bidirectional Wnt signaling between endoderm and mesoderm promotes trachea development. Activating Wnt, Bmp signaling in mouse embryonic stem cell (ESC)-derived lateral plate mesoderm (LPM) generates tracheal mesoderm containing chondrocytes and smooth muscle cells. For human ESC-derived LPM, SHH activation is required along with WNT to generate proper tracheal mesoderm. Together, these findings may contribute to developing applications for human tracheal tissue repair. |
記述: | 呼吸器の発生をつかさどるメカニズムの解明 --発生現象の発見に基づくES細胞から気管組織の作出へ--. 京都大学プレスリリース. 2020-09-03. |
著作権等: | © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
URI: | http://hdl.handle.net/2433/254164 |
DOI(出版社版): | 10.1038/s41467-020-17969-w |
PubMed ID: | 32855415 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2020-09-03 |
出現コレクション: | 学術雑誌掲載論文等 |
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