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Title: Absorption and Tissue Distribution of Siphonaxanthin from Green Algae
Authors: Li, Zhuosi
Zheng, Jiawen
Luo, Xiaolin
Manabe, Yuki  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-5663-0074 (unconfirmed)
Hirata, Takashi
Sugawara, Tatsuya  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-1203-5521 (unconfirmed)
Author's alias: 真鍋, 祐樹
平田, 孝
菅原, 達也
Keywords: siphonaxanthin
dehydro-metabolite
white adipose tissue
metabolic pathway in vivo
Issue Date: Jun-2020
Publisher: MDPI AG
Journal title: Marine Drugs
Volume: 18
Issue: 6
Thesis number: 291
Abstract: Siphonaxanthin has been known to possess inhibitory effects against obesity, inflammation, and angiogenesis. However, little information on its in vivo bioavailability and biotransformation is available. To assess the bioavailability and metabolism of siphonaxanthin, its absorption and accumulation were evaluated using intestinal Caco-2 cells and Institute of Cancer Research (ICR) mice. Siphonaxanthin was absorbed and exhibited non-uniform accumulation and distribution patterns in tissues of ICR mice. Notably, in addition to siphonaxanthin, three main compounds were detected following dietary administration of siphonaxanthin. Because the compounds showed changes on mass spectra compared with that of siphonaxanthin, they were presumed to be metabolites of siphonaxanthin in ICR mice. Siphonaxanthin mainly accumulated in stomach and small intestine, while putative metabolites of siphonaxanthin mainly accumulated in liver and adipose tissues. Furthermore, siphonaxanthin and its putative metabolites selectively accumulated in white adipose tissue (WAT), especially mesenteric WAT. These results provide useful evidence regarding the in vivo bioactivity of siphonaxanthin. In particular, the results regarding the specific accumulation of siphonaxanthin and its metabolites in WAT have important implications for understanding their anti-obesity effects and regulatory roles in lipid metabolism.
Rights: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
URI: http://hdl.handle.net/2433/254193
DOI(Published Version): 10.3390/md18060291
PubMed ID: 32492769
Appears in Collections:Journal Articles

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