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Title: Light-mediated control of Gene expression in mammalian cells
Authors: Yamada, Mayumi  kyouindb  KAKEN_id  orcid (unconfirmed)
Nagasaki, Shinji C.
Ozawa, Takeaki
Imayoshi, Itaru  kyouindb  KAKEN_id  orcid (unconfirmed)
Author's alias: 山田, 真弓
長崎, 真治
小澤, 岳昌
今吉, 格
Keywords: Optogenetics
Gene expression
Tet system
Gal4/UAS system
Issue Date: Mar-2020
Publisher: Elsevier BV
Journal title: Neuroscience Research
Volume: 152
Start page: 66
End page: 77
Abstract: Taking advantage of the recent development of genetically-defined photo-activatable actuator molecules, cellular functions, including gene expression, can be controlled by exposure to light. Such optogenetic strategies enable precise temporal and spatial manipulation of targeted single cells or groups of cells at a level hitherto impossible. In this review, we introduce light-controllable gene expression systems exploiting blue or red/far-red wavelengths and discuss their inherent properties potentially affecting induced downstream gene expression patterns. We also discuss recent advances in optical devices that will extend the application of optical gene expression control technologies into many different areas of biology and medicine.
Rights: © 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (
DOI(Published Version): 10.1016/j.neures.2019.12.018
PubMed ID: 31923448
Appears in Collections:Journal Articles

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