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ファイル | 記述 | サイズ | フォーマット | |
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j.neures.2019.12.018.pdf | 1.89 MB | Adobe PDF | 見る/開く |
タイトル: | Light-mediated control of Gene expression in mammalian cells |
著者: | Yamada, Mayumi https://orcid.org/0000-0001-6272-3704 (unconfirmed) Nagasaki, Shinji C. Ozawa, Takeaki Imayoshi, Itaru https://orcid.org/0000-0001-9728-481X (unconfirmed) |
著者名の別形: | 山田, 真弓 長崎, 真治 小澤, 岳昌 今吉, 格 |
キーワード: | Optogenetics Gene expression Tet system Gal4/UAS system Cry2-CIB1 |
発行日: | Mar-2020 |
出版者: | Elsevier BV |
誌名: | Neuroscience Research |
巻: | 152 |
開始ページ: | 66 |
終了ページ: | 77 |
抄録: | Taking advantage of the recent development of genetically-defined photo-activatable actuator molecules, cellular functions, including gene expression, can be controlled by exposure to light. Such optogenetic strategies enable precise temporal and spatial manipulation of targeted single cells or groups of cells at a level hitherto impossible. In this review, we introduce light-controllable gene expression systems exploiting blue or red/far-red wavelengths and discuss their inherent properties potentially affecting induced downstream gene expression patterns. We also discuss recent advances in optical devices that will extend the application of optical gene expression control technologies into many different areas of biology and medicine. |
著作権等: | © 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
URI: | http://hdl.handle.net/2433/254695 |
DOI(出版社版): | 10.1016/j.neures.2019.12.018 |
PubMed ID: | 31923448 |
出現コレクション: | 学術雑誌掲載論文等 |
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