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タイトル: 腎原発Ewing肉腫に対して集学的治療を行った1例
その他のタイトル: A Case of Primary Ewing Sarcoma of the Kidney Treated with Multidisciplinary Approach
著者: 今井, 一登  KAKEN_name
山﨑, 俊成  KAKEN_name
坂元, 宏匡  KAKEN_name
中村, 清直  KAKEN_name
溝脇, 尚志  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-8135-8746 (unconfirmed)
小川, 修  KAKEN_name
青山, 輝義  KAKEN_name
著者名の別形: Imai, Kazuto
Yamasaki, Toshinari
Sakamoto, Hiromasa
Nakamura, Kiyonao
Mizowaki, Takashi
Ogawa, Osamu
Aoyama, Teruyoshi
キーワード: Ewing sarcoma
Kidney
Soft part tumor
Multidisciplinary treatment
発行日: 30-Sep-2020
出版者: 泌尿器科紀要刊行会
誌名: 泌尿器科紀要
巻: 66
号: 9
開始ページ: 297
終了ページ: 302
抄録: A woman in her 40s visited our hospital for further examination and treatment of a left renal tumor. Imaging studies showed that the patient had a large left renal tumor, 10.5 cm in diameter, which contained foci of necrosis. Open left radical nephrectomy was performed. In pathological examination, hematoxylin-eosin staining showed uniform small round cells with alveolar growth. Immunohistochemistry findings showed that CD99 and NKX2. 2 were positive, and synaptophysin was focally positive. Fluorescence in situ hybridization confirmed (11 ; 22) (q24 ; q12) chromosomal translocation which led to diagnosis of primary Ewing sarcoma of the kidney. Two months after the surgery, new tumors were found inside and outside of the left psoas muscles and in the left paracolic gutter. Six courses of chemotherapy were administered with VDC (vincristine/doxorubicin/cyclophosphamide) and IE (ifosfamide/etoposide). After completing the combined chemotherapy, the recurrent tumors disappeared completely on imaging. To prevent further recurrence, external radiation was administered to the left retroperitoneal region. About 16 months after the surgery, numerous new tumors appeared in the left retroperitoneal, left pleura, and erector spinae muscles. Chemotherapy was resumed following radiotherapy, and then trabectedin was administered. However, she eventually died of progressive disease at 26 months after the surgery.
著作権等: 許諾条件により本文は2021/10/01に公開
DOI: 10.14989/ActaUrolJap_66_9_297
URI: http://hdl.handle.net/2433/255211
PubMed ID: 32988166
出現コレクション:Vol.66 No.9

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