ダウンロード数: 129
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
bloodadvances.2020002457.pdf | 1.07 MB | Adobe PDF | 見る/開く |
完全メタデータレコード
DCフィールド | 値 | 言語 |
---|---|---|
dc.contributor.author | Matsuo, Hidemasa | en |
dc.contributor.author | Yoshida, Kenichi | en |
dc.contributor.author | Nakatani, Kana | en |
dc.contributor.author | Harata, Yutarou | en |
dc.contributor.author | Higashitani, Moe | en |
dc.contributor.author | Ito, Yuri | en |
dc.contributor.author | Kamikubo, Yasuhiko | en |
dc.contributor.author | Shiozawa, Yusuke | en |
dc.contributor.author | Shiraishi, Yuichi | en |
dc.contributor.author | Chiba, Kenichi | en |
dc.contributor.author | Tanaka, Hiroko | en |
dc.contributor.author | Okada, Ai | en |
dc.contributor.author | Nannya, Yasuhito | en |
dc.contributor.author | Takeda, June | en |
dc.contributor.author | Ueno, Hiroo | en |
dc.contributor.author | Kiyokawa, Nobutaka | en |
dc.contributor.author | Tomizawa, Daisuke | en |
dc.contributor.author | Taga, Takashi | en |
dc.contributor.author | Tawa, Akio | en |
dc.contributor.author | Miyano, Satoru | en |
dc.contributor.author | Meggendorfer, Manja | en |
dc.contributor.author | Haferlach, Claudia | en |
dc.contributor.author | Ogawa, Seishi | en |
dc.contributor.author | Adachi, Souichi | en |
dc.contributor.alternative | 松尾, 英将 | ja |
dc.contributor.alternative | 吉田, 健一 | ja |
dc.contributor.alternative | 中谷, 香菜 | ja |
dc.contributor.alternative | 原田, 優太郎 | ja |
dc.contributor.alternative | 東谷, 萌絵 | ja |
dc.contributor.alternative | 伊東, 優里 | ja |
dc.contributor.alternative | 上久保, 靖彦 | ja |
dc.contributor.alternative | 塩澤, 裕介 | ja |
dc.contributor.alternative | 白石, 友一 | ja |
dc.contributor.alternative | 千葉, 健一 | ja |
dc.contributor.alternative | 田中, 洋子 | ja |
dc.contributor.alternative | 岡田, 愛 | ja |
dc.contributor.alternative | 南谷, 泰仁 | ja |
dc.contributor.alternative | 竹田, 淳恵 | ja |
dc.contributor.alternative | 上野, 浩生 | ja |
dc.contributor.alternative | 清河, 信敬 | ja |
dc.contributor.alternative | 富澤, 大輔 | ja |
dc.contributor.alternative | 多賀, 崇 | ja |
dc.contributor.alternative | 多和, 昭雄 | ja |
dc.contributor.alternative | 宮野, 悟 | ja |
dc.contributor.alternative | 小川, 誠司 | ja |
dc.contributor.alternative | 足立, 壯一 | ja |
dc.date.accessioned | 2020-10-09T02:03:54Z | - |
dc.date.available | 2020-10-09T02:03:54Z | - |
dc.date.issued | 2020-10-13 | - |
dc.identifier.issn | 2473-9529 | - |
dc.identifier.uri | http://hdl.handle.net/2433/255477 | - |
dc.description | 急性骨髄性白血病の予後を予測する新規マーカーを発見 --リスクに応じた適切な治療につながる可能性--. 京都大学プレスリリース. 2020-10-02. | ja |
dc.description.abstract | Mixed-lineage leukemia (MLL) gene rearrangements are among the most frequent chromosomal abnormalities in acute myeloid leukemia (AML). MLL fusion patterns are associated with the patient’s prognosis; however, their relationship with driver mutations is unclear. We conducted sequence analyses of 338 genes in pediatric patients with MLL-rearranged (MLL-r) AML (n = 56; JPLSG AML-05 study) alongside data from the TARGET study’s pediatric cohorts with MLL-r AML (n = 104), non–MLL-r AML (n = 581), and adult MLL-r AML (n = 81). KRAS mutations were most frequent in pediatric patients with high-risk MLL fusions (MLL-MLLLT10, MLL-MLLT4, and MLL-MLLT1). Pediatric patients with MLL-r AML (n = 160) and a KRAS mutation (KRAS-MT) had a significantly worse prognosis than those without a KRAS mutation (KRAS-WT) (5-year event-free survival [EFS]: 51.8% vs 18.3%, P < .0001; 5-year overall survival [OS]: 67.3% vs 44.3%, P = .003). The adverse prognostic impact of KRAS mutations was confirmed in adult MLL-r AML. KRAS mutations were associated with adverse prognoses in pediatric patients with both high-risk (MLLT10+MLLT4+MLLT1; n = 60) and intermediate-to-low–risk (MLLT3+ELL+others; n = 100) MLL fusions. The prognosis did not differ significantly between patients with non–MLL-r AML with KRAS-WT or KRAS-MT. Multivariate analysis showed the presence of a KRAS mutation to be an independent prognostic factor for EFS (hazard ratio [HR], 2.21; 95% confidence interval [CI], 1.35-3.59; P = .002) and OS (HR, 1.85; 95% CI, 1.01-3.31; P = .045) in MLL-r AML. The mutation is a distinct adverse prognostic factor in MLL-r AML, regardless of risk subgroup, and is potentially useful for accurate treatment stratification. This trial was registered at the UMIN (University Hospital Medical Information Network) Clinical Trials Registry (UMIN-CTR; http://www.umin.ac.jp/ctr/index.htm) as #UMIN000000511. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Society of Hematology | en |
dc.title | Fusion partner–specific mutation profiles and KRAS mutations as adverse prognostic factors in MLL-rearranged AML | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Blood Advances | en |
dc.identifier.volume | 4 | - |
dc.identifier.issue | 19 | - |
dc.identifier.spage | 4623 | - |
dc.identifier.epage | 4631 | - |
dc.relation.doi | 10.1182/bloodadvances.2020002457 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 32991719 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/ja/research-news/2020-10-02 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 19K16832 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。