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Title: Development of Helical Myofiber Tracts in the Human Fetal Heart: Analysis of Myocardial Fiber Formation in the Left Ventricle From the Late Human Embryonic Period Using Diffusion Tensor Magnetic Resonance Imaging
Authors: Nishitani, Saori
Torii, Narisa
Imai, Hirohiko  kyouindb  KAKEN_id
Haraguchi, Ryo
Yamada, Shigehito
Takakuwa, Tetsuya  kyouindb  KAKEN_id  orcid (unconfirmed)
Author's alias: 西谷, 早織
鳥居, 也紗
今井, 宏彦
原口, 亮
山田, 重人
高桑, 徹也
Keywords: myocardial fiber orientation
fetal heart
fetal development
diffusion tensor magnetic resonance imaging
human late embryonic period
Issue Date: 6-Oct-2020
Publisher: Ovid Technologies (Wolters Kluwer Health)
Journal title: Journal of the American Heart Association
Volume: 9
Issue: 19
Thesis number: e016422
Abstract: Background: Detection of the fiber orientation pattern of the myocardium using diffusion tensor magnetic resonance imaging lags ≈12 weeks of gestational age (WGA) behind fetal myocardial remodeling with invasion by the developing coronary vasculature (8 WGA). We aimed to use diffusion tensor magnetic resonance imaging tractography to characterize the evolution of fiber architecture in the developing human heart from the later embryonic period. Methods and Results: Twenty human specimens (8–24 WGA) from the Kyoto Collection of Human Embryos and Fetuses, including specimens from the embryonic period (Carnegie stages 20–23), were used. Diffusion tensor magnetic resonance imaging data were acquired with a 7T magnetic resonance system. Fractional anisotropy and helix angle were calculated using standard definitions. In all samples, the fibers ran helically in an organized pattern in both the left and right ventricles. A smooth transmural change in helix angle values (from positive to negative) was detected in all 16 directions of the ventricles. This feature was observed in almost all small (Carnegie stage 23) and large samples. A higher fractional anisotropy value was detected at the outer side of the anterior wall and septum at Carnegie stage 20 to 22, which spread around the ventricular wall at Carnegie stage 23 and in the early fetal samples (11–12 WGA). The fractional anisotropy value of the left ventricular walls decreased in samples with ≥13 WGA, which remained low (≈0.09) in larger samples. Conclusions: From the human late embryonic period (from 8 WGA), the helix angle arrangement of the myocardium is comparable to that of the adult, indicating that the myocardial structure blueprint, organization, and integrity are already formed.
Description: ヒト胎児心臓の心筋線維方向を追跡 --受精後8週の心筋線維は成人と同じ配列をする--. 京都大学プレスリリース. 2020-10-09.
Rights: © 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
DOI(Published Version): 10.1161/JAHA.120.016422
PubMed ID: 32993423
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