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タイトル: | Hyperglycemia in non-obese patients with type 2 diabetes is associated with low muscle mass: The Multicenter Study for Clarifying Evidence for Sarcopenia in Patients with Diabetes Mellitus |
著者: | Sugimoto, Ken Tabara, Yasuharu Ikegami, Hiroshi Takata, Yasunori Kamide, Kei Ikezoe, Tome Kiyoshige, Eri Makutani, Yukako Onuma, Hiroshi Gondo, Yasuyuki Ikebe, Kazunori Ichihashi, Noriaki ![]() ![]() ![]() Tsuboyama, Tadao Matsuda, Fumihiko Kohara, Katsuhiko Kabayama, Mai Fukuda, Masahiro Katsuya, Tomohiro Osawa, Haruhiko Hiromine, Yoshihisa Rakugi, Hiromi |
著者名の別形: | 池添, 冬芽 市橋, 則明 |
キーワード: | Sarcopenia Skeletal muscle mass Type 2 diabetes |
発行日: | Nov-2019 |
出版者: | Wiley |
誌名: | Journal of diabetes investigation |
巻: | 10 |
号: | 6 |
開始ページ: | 1471 |
終了ページ: | 1479 |
抄録: | AIMS/INTRODUCTION: Hyperglycemia is a risk factor for sarcopenia when comparing individuals with and without diabetes. However, no studies have investigated whether the findings could be extrapolated to patients with diabetes with relatively higher glycemic levels. Here, we aimed to clarify whether glycemic control was associated with sarcopenia in patients with type 2 diabetes. MATERIALS AND METHODS: Study participants consisted of patients with type 2 diabetes (n = 746, the average age was 69.9 years) and an older general population (n = 2, 067, the average age was 68.2 years). Sarcopenia was defined as weak grip strength or slow usual gait speed and low skeletal mass index. RESULTS: Among patients with type 2 diabetes, 52 were diagnosed as having sarcopenia. The frequency of sarcopenia increased linearly with glycated hemoglobin (HbA1c) level, particularly in lean individuals (HbA1c <6.5%, 7.0%, ≥6.5% and <7.0%: 18.5%; HbA1c ≥7.0% and <8.0%: 20.3%; HbA1c ≥8.0%: 26.7%). The linear association was independent of major covariates, including anthropometric factors and duration of diabetes (HbA1c <6.5%: reference; ≥6.5% and <7.0%: odds ratio [OR] 4.38, P = 0.030; HbA1c ≥7.0% and <8.0%: 4.29, P = 0.024; HbA1c ≥8.0%: 7.82, P = 0.003). HbA1c level was specifically associated with low skeletal mass index (HbA1c ≥8.0%: OR 5.42, P < 0.001) rather than weak grip strength (OR 1.89, P = 0.058) or slow gait speed (OR 1.13, P = 0.672). No significant association was observed in the general population with a better glycemic profile. CONCLUSIONS: Poor glycemic control in patients with diabetes was associated with low muscle mass. |
著作権等: | © 2019 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
URI: | http://hdl.handle.net/2433/255606 |
DOI(出版社版): | 10.1111/jdi.13070 |
PubMed ID: | 31074209 |
出現コレクション: | 学術雑誌掲載論文等 |
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