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タイトル: | Low serum free light chain is associated with risk of COPD exacerbation |
著者: | Tanimura, Kazuya Sato, Susumu https://orcid.org/0000-0002-9626-1090 (unconfirmed) Sato, Atsuyasu Tanabe, Naoya https://orcid.org/0000-0002-7481-0212 (unconfirmed) Hasegawa, Koichi Uemasu, Kiyoshi Hamakawa, Yoko Hirai, Toyohiro Muro, Shigeo |
著者名の別形: | 谷村, 和哉 佐藤, 晋 佐藤, 篤靖 田辺, 直也 長谷川, 浩一 上桝, 潔 濱川, 瑶子 平井, 豊博 室, 繁郎 |
発行日: | 1-Apr-2020 |
出版者: | European Respiratory Society (ERS) |
誌名: | ERJ Open Research |
巻: | 6 |
号: | 2 |
論文番号: | 00288-2019 |
抄録: | Background: Most exacerbations of chronic obstructive pulmonary disease (COPD) are triggered by respiratory tract infections. Adaptive immunity via antibody production is important in preventing infections. Impaired antibody production is reported to be associated with an increased risk of exacerbations of COPD. In the present study, we elucidated whether reduced free light chains (FLCs), which are excessive amounts of light chains produced during antibody synthesis and can be used to estimate systemic antibody production, may be a promising biomarker to predict the risk of exacerbations of COPD. Methods: We enrolled stable male patients with COPD and prospectively observed them for 2 years. At baseline, serum combined FLC (cFLC; sum of kappa and lambda values) and pulmonary function were evaluated. Exacerbation was defined as a worsening of symptoms requiring treatments with antibiotics, corticosteroids or both. Results: 63 patients with stable COPD were enrolled (72.8±8.1 years, GOLD A/B/C/D=24/28/6/5), and 51 patients completed the 2-year follow-up. Serum cFLC was 31.1 mg·L−1 on average and ranged widely (1.4 to 89.9 mg·L−1). The patients with low cFLC (below the mean−sd, n=6) experienced a significantly shorter time to the first exacerbation of COPD (p<0.0001 by the log-rank test). A multivariate Cox proportional hazard model, including the COPD assessment test score, % predicted forced expiratory volume in 1 s (FEV1 % pred), and number of previous exacerbations demonstrated that low cFLC and low FEV1 % pred were independently and significantly correlated with the risk for exacerbations of COPD. Conclusion: Low cFLC may be a B-cell-associated novel biomarker associated with risk of COPD exacerbation. |
著作権等: | © ERS 2020. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. |
URI: | http://hdl.handle.net/2433/255619 |
DOI(出版社版): | 10.1183/23120541.00288-2019 |
PubMed ID: | 32665945 |
出現コレクション: | 学術雑誌掲載論文等 |
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