|Title:||Two Functionally Distinct Serotonergic Projections into Hippocampus|
McHugh, J. Thomas
Hayashi, Yasunori https://orcid.org/0000-0002-7560-3004 (unconfirmed)
|Author's alias:||水田, 恒太郎|
|Publisher:||Society for Neuroscience|
|Journal title:||The Journal of Neuroscience|
|Abstract:||Hippocampus receives dense serotonergic input specifically from raphe nuclei. However, what information is carried by this input and its impact on behavior has not been fully elucidated. Here we used in vivo two-photon imaging of activity of hippocampal median raphe projection fibers in behaving male and female mice and identified two distinct populations: one linked to reward delivery and the other to locomotion. Local optogenetic manipulation of these fibers confirmed a functional role for these projections in the modulation of reward-induced behavior. The diverse function of serotonergic inputs suggests a key role in integrating locomotion and reward information into the hippocampal CA1.|
|Rights:||© 2020 Authors. This paper was deposited under 'AUTHOR LICENSE POLICY'. (http://www.jneurosci.org/content/rights-permissions)|
The full-text file will be made open to the public on 17 December 2022 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
|Appears in Collections:||Journal Articles |
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