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タイトル: | Assessing the Carcinogenic Potential of Low Dose Exposures to Chemical Mixtures in the Environment: Replicative immortality |
著者: | Goodson, William H. Lowe, Leroy Carpenter, O. David Gilbertson, Michael Manaf Ali, Abdul Lopez de Cerain Salsamendi, Adela Lasfar, Ahmed Carnero, Amancio Azqueta, Amaya Amedei, Amedeo Charles, K. Amelia Laird, Dale W. Koch, C. Daniel Carlin, J. Danielle Felsher, W. Dean Roy, Debasish Brown, G. Dustin Ratovitski, Edward Ryan, P. Elizabeth Corsini, Emanuela Rojas, Emilio Manjili, H. Masoud Moon, Eun-Yi Laconi, Ezio Marongiu, Fabio Al-Mulla, Fahd Chiaradonna, Ferdinando Darroudi, Firouz Martin, Francis L. Van Schooten, J. Frederik Goldberg, S. Gary Wagemaker, Gerard Lleonart, E. Matilde Nangami, N. Gladys Calaf, M. Gloria Williams, P. Graeme Wolf, T. Gregory Koppen, Gudrun Brunborg, Gunnar Lyerly, H. Kim Krishnan, Harini Ab Hamid, Hasiah Yasaei, Hemad Xia, Menghang Sone, Hideko Kondoh, Hiroshi Salem, K. Hosni Hsu, Hsue-Yin Park, Hyun Ho Koturbash, Igor Miousse, R. Isabelle Scovassi, A.Ivana Klaunig, E. James Vondráček, Jan Gonzalez Guzman, J. Michael Raju, Jayadev Roman, Jesse Wise, John Pierce Whitfield, R. Jonathan Woodrick, Jordan Christopher, A. Joseph Ochieng, Josiah Martinez-Leal, Juan Fernando Weisz, Judith Kravchenko, Julia Karamouzis, V. Michalis Sun, Jun Prudhomme, R. Kalan Narayanan, Kannan Badri Cohen-Solal, A. Karine Moorwood, Kim Gonzalez, Laetitia Soucek, Laura Jian, Le D’Abronzo, S. Leandro Lin, Liang-Tzung Kirsch-Volders, Micheline Li, Lin Gulliver, Linda McCawley, J. Lisa Memeo, Lorenzo Vermeulen, Louis Leyns, Luc Zhang, Luoping Valverde, Mahara Khatami, Mahin Romano, Maria Fiammetta Vaccari, Monica Chapellier, Marion Williams, A. Marc Wade, Mark Kuemmerle, B. Nancy Singh, Neetu Cruickshanks, Nichola Collins, R. Andrew Kleinstreuer, Nicole van Larebeke, Nik Ahmed, Nuzhat Ogunkua, Olugbemiga Krishnakumar, P. K. Vadgama, Pankaj Marignani, A. Paola Ghosh, M. Paramita Ostrosky-Wegman, Patricia Thompson, A. Patricia Ward, Andrew Dent, Paul Heneberg, Petr Darbre, Philippa Leung, Po Sing Nangia-Makker, Pratima Cheng, Qiang (Shawn) Robey, R. Brooks Al-Temaimi, Rabeah Roy, Rabindra Andrade-Vieira, Rafaela Salzberg, C. Anna Sinha, K. Ranjeet Mehta, Rekha Vento, Renza Di Fiore, Riccardo Ponce-Cusi, Richard Dornetshuber-Fleiss, Rita Nahta, Rita Castellino, C. Robert Palorini, Roberta Hamid, A. Roslida Colacci, Anna Maria Langie, A. S. Sabine Eltom, E. Sakina Brooks, A. Samira Ryeom, Sandra Wise, S. Sandra Bay, N. Sarah Harris, A. Shelley Papagerakis, Silvana Romano, Simona Pavanello, Sofia Olsen, Ann-Karin Eriksson, Staffan Forte, Stefano Casey, C. Stephanie Luanpitpong, Sudjit Lee, Tae-Jin Otsuki, Takemi Chen, Tao Massfelder, Thierry Sanderson, Thomas Guarnieri, Tiziana Berg, Arthur Hultman, Tove Dormoy, Valérian Odero-Marah, Valerie Sabbisetti, Venkata Maguer-Satta, Veronique Rathmell, W.Kimryn Engström, Wilhelm Decker, K. William Bisson, H. William Rojanasakul, Yon Barclay, J. Barry Luqmani, Yunus Chen, Zhenbang Hu, Zhiwei Zhou, P. Binhua Blanco-Aparicio, Carmen Baglole, J. Carolyn Dong, Chenfang Mondello, Chiara Hsu, Chia-Wen Naus, C. Christian Yedjou, Clement Curran, S. Colleen |
著者名の別形: | 近藤, 祥司 |
発行日: | Jun-2015 |
出版者: | Oxford University Press (OUP) |
誌名: | Carcinogenesis |
巻: | 36 |
号: | Suppl_1 |
開始ページ: | S254 |
終了ページ: | S296 |
抄録: | Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety ‘Mode of Action’ framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology. |
記述: | A correction has been published: Carcinogenesis, Volume 37, Issue 3, March 2016, Page 344, https://doi.org/10.1093/carcin/bgv155. |
著作権等: | © The Author 2015. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
URI: | http://hdl.handle.net/2433/255638 |
DOI(出版社版): | 10.1093/carcin/bgv039 |
PubMed ID: | 26106142 |
関連リンク: | https://doi.org/10.1093/carcin/bgv155 |
出現コレクション: | 学術雑誌掲載論文等 |
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