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タイトル: | Expression of progenitor cell/immature neuron markers does not present definitive evidence for adult neurogenesis |
著者: | Hagihara, Hideo Murano, Tomoyuki Ohira, Koji Miwa, Miki Nakamura, Katsuki Miyakawa, Tsuyoshi |
著者名の別形: | 中村, 克樹 |
キーワード: | Hippocampus Dentate gyrus Granule cells Dematuration Adult neurogenesis |
発行日: | Dec-2019 |
出版者: | Springer Nature |
誌名: | Molecular brain |
巻: | 12 |
論文番号: | 108 |
抄録: | It is agreed upon that adult hippocampal neurogenesis (AHN) occurs in the dentate gyrus (DG) in rodents. However, the existence of AHN in humans, particularly in elderly individuals, remains to be determined. Recently, several studies reported that neural progenitor cells, neuroblasts, and immature neurons were detected in the hippocampus of elderly humans, based on the expressions of putative markers for these cells, claiming that this provides evidence of the persistence of AHN in humans. Herein, we briefly overview the phenomenon that we call “dematuration, ” in which mature neurons dedifferentiate to a pseudo-immature status and re-express the molecular markers of neural progenitor cells and immature neurons. Various conditions can easily induce dematuration, such as inflammation and hyper-excitation of neurons, and therefore, the markers for neural progenitor cells and immature neurons may not necessarily serve as markers for AHN. Thus, the aforementioned studies have not presented definitive evidence for the persistence of hippocampal neurogenesis throughout adult life in humans, and we would like to emphasize that those markers should be used cautiously when presented as evidence for AHN. Increasing AHN has been considered as a therapeutic target for Alzheimer’s disease (AD); however, given that immature neuronal markers can be re-expressed in mature adult neurons, independent of AHN, in various disease conditions including AD, strategies to increase the expression of these markers in the DG may be ineffective or may worsen the symptoms of such diseases. |
著作権等: | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
URI: | http://hdl.handle.net/2433/255651 |
DOI(出版社版): | 10.1186/s13041-019-0522-8 |
PubMed ID: | 31823803 |
出現コレクション: | 学術雑誌掲載論文等 |
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