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タイトル: | Expression of Bitter Taste Receptors in the Intestinal Cells of Non-Human Primates |
著者: | Imai, Hiroo Hakukawa, Miho Hayashi, Misa Iwatsuki, Ken Masuda, Katsuyoshi |
著者名の別形: | 今井, 啓雄 伯川, 美穂 林, 美紗 |
キーワード: | bitter taste receptors RNAseq macaque |
発行日: | Feb-2020 |
出版者: | MDPI AG |
誌名: | International Journal of Molecular Sciences |
巻: | 21 |
号: | 3 |
論文番号: | 902 |
抄録: | (1) Background: Recent studies have investigated the expression of taste-related genes in the organs of various animals, including humans; however, data for additional taxa are needed to facilitate comparative analyses within and among species. (2) Methods: We investigated the expression of taste-related genes in the intestines of rhesus macaques, the non-human primates most commonly used in experimental models. (3) Results: Based on RNAseq and qRT-PCR, genes encoding bitter taste receptors and the G-protein gustducin were expressed in the gut of rhesus macaques. RNAscope analysis showed that one of the bitter receptors, TAS2R38, was expressed in some cells in the small intestine, and immunohistochemical analysis revealed the presence of T2R38-positive cells in the villi of the intestines. (4) Conclusions: These results suggest that bitter receptors are expressed in the gut of rhesus macaques, supporting the use of macaques as a model for studies of human taste, including gut analyses. |
著作権等: | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
URI: | http://hdl.handle.net/2433/259099 |
DOI(出版社版): | 10.3390/ijms21030902 |
PubMed ID: | 32019181 |
出現コレクション: | 学術雑誌掲載論文等 |
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