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Title: Intact in vivo visualization of telencephalic microvasculature in medaka using optical coherence tomography
Authors: Suzuki, Takashi
Ueno, Tomohiro  kyouindb  KAKEN_id
Oishi, Naoya  kyouindb  KAKEN_id  orcid (unconfirmed)
Fukuyama, Hidenao
Author's alias: 上野, 智弘
大石, 直也
福山, 秀直
Issue Date: Dec-2020
Publisher: Springer Nature
Journal title: Scientific Reports
Volume: 10
Thesis number: 19831
Abstract: To date, various human disease models in small fish—such as medaka (Oryzias lapties)--have been developed for medical and pharmacological studies. Although genetic and environmental homogeneities exist, disease progressions can show large individual differences in animal models. In this study, we established an intact in vivo angiographic approach and explored vascular networks in the telencephalon of wild-type adult medaka using the spectral-domain optical coherence tomography. Our approach, which required neither surgical operations nor labeling agents, allowed to visualize blood vessels in medaka telencephala as small as about 8 µm, that is, almost the size of the blood cells of medaka. Besides, we could show the three-dimensional microvascular distribution in the medaka telencephalon. Therefore, the intact in vivo imaging via optical coherence tomography can be used to perform follow-up studies on cerebrovascular alterations in metabolic syndrome and their associations with neurodegenerative disease models in medaka.
Rights: © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit
DOI(Published Version): 10.1038/s41598-020-76468-6
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