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Title: Reduced glycemic variability and flexible graft function after islet transplantation: A case report
Authors: Nakamura, Toshihiro
Fujikura, Junji
Anazawa, Takayuki
Ito, Ryo
Ogura, Masahito  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-7107-2752 (unconfirmed)
Okajima, Hideaki
Noguchi, Hirofumi
Uemoto, Shinji
Inagaki, Nobuya
Author's alias: 藤倉, 純二
穴澤, 貴行
小倉, 雅仁
岡島, 英明
野口, 洋文
上本, 伸二
稲垣, 暢也
Keywords: Islet transplantation
Intermittently scanned continuous glucose monitoring
Mixed‐meal test
Issue Date: Nov-2020
Publisher: Wiley
Journal title: Journal of Diabetes Investigation
Volume: 11
Issue: 6
Start page: 1677
End page: 1680
Abstract: To date, studies of patients with islet transplantation addressing intermittently scanned continuous glucose monitoring profile and the flexibility of the graft islet function under different doses of insulin administration, both of which reflect the real daily life of patients, are quite limited. Here, we report a case of a 46‐year‐old woman who received islet transplantation after kidney transplantation. The patient was followed up over a period of 2 years after initial islet transplantation. Our results show that intermittently scanned continuous glucose monitoring can be useful for monitoring the reduction of glycemic variability, and suggest the appropriate regulation of insulin secretion from graft islets during mixed‐meal test by using different doses of exogenous insulin administration. Additionally, during the 2‐year observational period, glucagon elevation was detected only at hypoglycemia, whereas the level was within the normal range at normoglycemia or hyperglycemia.
Rights: © 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
URI: http://hdl.handle.net/2433/259214
DOI(Published Version): 10.1111/jdi.13292
PubMed ID: 32431082
Appears in Collections:Journal Articles

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