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タイトル: Logical design of oral glucose ingestion pattern minimizing blood glucose in humans
著者: Fujii, Masashi
Murakami, Yohei
Karasawa, Yasuaki
Sumitomo, Yohei
Fujita, Suguru
Koyama, Masanori
Uda, Shinsuke
Kubota, Hiroyuki
Inoue, Hiroshi
Konishi, Katsumi
Oba, Shigeyuki
Ishii, Shin  KAKEN_id
Kuroda, Shinya
著者名の別形: 村上, 陽平
大羽, 成征
石井, 信
発行日: 2-Dec-2019
出版者: Springer Nature
誌名: npj Systems Biology and Applications
巻: 5
論文番号: 31
抄録: Excessive increase in blood glucose level after eating increases the risk of macroangiopathy, and a method for not increasing the postprandial blood glucose level is desired. However, a logical design method of the dietary ingestion pattern controlling the postprandial blood glucose level has not yet been established. We constructed a mathematical model of blood glucose control by oral glucose ingestion in three healthy human subjects, and predicted that intermittent ingestion 30 min apart was the optimal glucose ingestion patterns that minimized the peak value of blood glucose level. We confirmed with subjects that this intermittent pattern consistently decreased the peak value of blood glucose level. We also predicted insulin minimization pattern, and found that the intermittent ingestion 30 min apart was optimal, which is similar to that of glucose minimization pattern. Taken together, these results suggest that the glucose minimization is achieved by suppressing the peak value of insulin concentration, rather than by enhancing insulin concentration. This approach could be applied to design optimal dietary ingestion patterns.
著作権等: © The Author(s) 2019 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
URI: http://hdl.handle.net/2433/259438
DOI(出版社版): 10.1038/s41540-019-0108-1
PubMed ID: 31508240
出現コレクション:学術雑誌掲載論文等

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