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sciadv.abf1798.pdf | 6.64 MB | Adobe PDF | 見る/開く |
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dc.contributor.author | Murashima-Suginami, A. | - |
dc.contributor.author | Kiso, H. | - |
dc.contributor.author | Tokita, Y. | - |
dc.contributor.author | Mihara, E. | - |
dc.contributor.author | Nambu, Y. | - |
dc.contributor.author | Uozumi, R. | - |
dc.contributor.author | Tabata, Y. | - |
dc.contributor.author | Bessho, K. | - |
dc.contributor.author | Takagi, J. | - |
dc.contributor.author | Sugai, M. | - |
dc.contributor.author | Takahashi, K. | - |
dc.contributor.alternative | 村島-杉並, 亜希子 | - |
dc.contributor.alternative | 喜早, ほのか | - |
dc.contributor.alternative | 時田, 義人 | - |
dc.contributor.alternative | 三原, 恵美子 | - |
dc.contributor.alternative | 南部, 由希子 | - |
dc.contributor.alternative | 魚住, 龍史 | - |
dc.contributor.alternative | 田畑, 泰彦 | - |
dc.contributor.alternative | 別所, 和久 | - |
dc.contributor.alternative | 高木, 淳一 | - |
dc.contributor.alternative | 菅井, 学 | - |
dc.contributor.alternative | 高橋, 克 | - |
dc.date.accessioned | 2021-02-16T06:05:04Z | - |
dc.date.available | 2021-02-16T06:05:04Z | - |
dc.date.issued | 2021-02-10 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.uri | http://hdl.handle.net/2433/261703 | - |
dc.description | 先天性無歯症に対する分子標的薬の開発 --USAG-1を標的分子とした歯再生治療--. 京都大学プレスリリース. 2021-02-15. | - |
dc.description.abstract | Uterine sensitization–associated gene-1 (USAG-1) deficiency leads to enhanced bone morphogenetic protein (BMP) signaling, leading to supernumerary teeth formation. Furthermore, antibodies interfering with binding of USAG-1 to BMP, but not lipoprotein receptor–related protein 5/6 (LRP5/6), accelerate tooth development. Since USAG-1 inhibits Wnt and BMP signals, the essential factors for tooth development, via direct binding to BMP and Wnt coreceptor LRP5/6, we hypothesized that USAG-1 plays key regulatory roles in suppressing tooth development. However, the involvement of USAG-1 in various types of congenital tooth agenesis remains unknown. Here, we show that blocking USAG-1 function through USAG-1 knockout or anti–USAG-1 antibody administration relieves congenital tooth agenesis caused by various genetic abnormalities in mice. Our results demonstrate that USAG-1 controls the number of teeth by inhibiting development of potential tooth germs in wild-type or mutant mice missing teeth. Anti–USAG-1 antibody administration is, therefore, a promising approach for tooth regeneration therapy. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Association for the Advancement of Science (AAAS) | - |
dc.rights | © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). | - |
dc.rights | This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | - |
dc.title | Anti–USAG-1 therapy for tooth regeneration through enhanced BMP signaling | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Science Advances | en |
dc.identifier.volume | 7 | - |
dc.identifier.issue | 7 | - |
dc.relation.doi | 10.1126/sciadv.abf1798 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | eabf1798 | - |
dc.identifier.pmid | 33579703 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/ja/research-news/2021-02-15-0 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 25463081 | - |
datacite.awardNumber | 17K118323 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
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