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Title: Two-Minute Quantitative Susceptibility Mapping From Three-Dimensional Echo-Planar Imaging: Accuracy, Reliability, and Detection Performance in Patients With Cerebral Microbleeds
Authors: Wicaksono, Pandu, Krishna
Fushimi, Yasutaka  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-1982-3168 (unconfirmed)
Nakajima, Satoshi  kyouindb  KAKEN_id
Yokota, Yusuke
Oshima, Sonoko
Otani, Sayo
Sakurama, Azusa
Shima, Atsushi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-3068-4621 (unconfirmed)
Sawamoto, Nobukatsu  kyouindb  KAKEN_id
Okada, Tomohisa
Nakamoto, Yuji  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-5783-8048 (unconfirmed)
Author's alias: 伏見, 育崇
Keywords: 3D-EPI
QSM
accuracy
reliability
microbleeds
MRI
Issue Date: Feb-2021
Publisher: Ovid Technologies (Wolters Kluwer Health)
Journal title: Investigative Radiology
Volume: 56
Issue: 2
Start page: 69
End page: 77
Abstract: Objectives: The aim of this study was to assess the accuracy, reliability, and cerebral microbleed (CMB) detection performance of 2-minute quantitative susceptibility mapping (QSM) from 3-dimensional echo-planar imaging (3D-EPI). Materials and Methods: Gadolinium phantom study was conducted using 3D-EPI, single–echo time (TE), and multi-TE gradient-recalled echo (GRE) sequences on two 3-T magnetic resonance (MR) scanners to assess the accuracy between measured and theoretical susceptibility values. The institutional review board approved this prospective study, and 40 healthy volunteers were enrolled with written consent between April 2018 and October 2019. Each underwent 3D-EPI, single-TE, and multi-TE GRE sequences consecutively on one 3-T MR scanner, and QSMs were calculated to assess the reliability of 3D-EPI QSM. Intraclass correlation coefficient (ICC), linear regression, and Bland-Altman plots were calculated. Patients with CMB who underwent both 3D-EPI and GRE QSM scans were retrospectively enrolled. Two radiologists evaluated images independently, and Cohen κ coefficients were calculated to compare CMB detection performance. Results: Phantom study showed excellent validity of 3D-EPI QSM on both MR scanners: Skyra, R2 = 0.996, P < 0.001, ICC = 0.997, mean difference, −2 ppb (95% confidence interval [CI], −45 to 40 ppb); Prisma, R2 = 0.992, P < 0.001, ICC = 0.988, mean difference, 15 ppb (95% CI, −67 to 97 ppb). A human study of 40 healthy volunteers (59 ± 13 years, 25 women) showed excellent reliability with 3D-EPI QSM for both single-TE and multi-TE GRE (R2 = 0.981, P < 0.001, ICC = 0.988; R2 = 0.983, P < 0.001, ICC = 0.990, respectively), supported by a Bland-Altman mean difference of 4 ppb (95% CI, −15 to 23 ppb) for single-TE GRE and 3 ppb (95% CI, −15 to 20 ppb) for multi-TE GRE. The CMB detection performance evaluation from 38 patients (51 ± 20 years, 20 women) showed almost perfect agreement between 3D-EPI and GRE QSM for both raters (κ = 0.923 and 0.942, P < 0.001). Conclusions: Faster QSM from 3D-EPI demonstrated excellent accuracy, reliability, and CMB detection performance.
Rights: © 2021 Wolters Kluwer Health | Lippincott Williams & Wilkins. This is a non-final version of an article published in final form in Wicaksono KP, Fushimi Y, Nakajima S, Yokota Y, Oshima S, Otani S, Sakurama A, Shima A, Sawamoto N, Okada T, Nakamoto Y. Two-Minute Quantitative Susceptibility Mapping From Three-Dimensional Echo-Planar Imaging: Accuracy, Reliability, and Detection Performance in Patients With Cerebral Microbleeds. Invest Radiol. 2021 Feb 1;56(2):69-77.
The full-text file will be made open to the public on 1 February 2022 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/261708
DOI(Published Version): 10.1097/RLI.0000000000000708
PubMed ID: 32649332
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