Downloads: 0

Files in This Item:
This article will be available after a certain embargo period.
Please see the "Rights" information in item metadata display about embargo date.
Title: Synthesis of Alkyl Bridged‐Tris‐α‐Amino Acids as C₃‐Symmetric and Linear Linkers
Authors: Uchino, Ayumi
Tsukano, Chihiro  kyouindb  KAKEN_id  orcid (unconfirmed)
Imamoto, Tsuneo
Irie, Kazuhiro  kyouindb  KAKEN_id  orcid (unconfirmed)
Author's alias: 内野, 歩美
塚野, 千尋
入江, 一浩
Keywords: Amino acids
Amyloid beta-peptides
Issue Date: 5-Mar-2021
Publisher: Wiley
Journal title: European Journal of Organic Chemistry
Volume: 2021
Issue: 9
Start page: 1370
End page: 1377
Abstract: Although bis‐α‐amino acids have been used to synthesize dimer models of aggregative peptides involved in neurodegenerative diseases, tris‐α‐amino acids are employed to a lesser extent for trimer models. The reported tris‐α‐amino acids substituted on the 1, 3, 5‐positions of an aromatic ring are not suitable for mimicking trimers due to their low flexibility and high planarity. Here, we design and synthesize two new alkyl bridged‐tris‐α‐amino acids with Fmoc protecting groups as new flexible linkers for trimer models.
Rights: This is the peer reviewed version of the following article: A. Uchino, C. Tsukano, T. Imamoto, K. Irie, Eur. J. Org. Chem. 2021, 2021, 1370, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
The full-text file will be made open to the public on 5 March 2022 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1002/ejoc.202001592
Appears in Collections:Journal Articles

Show full item record

Export to RefWorks

Export Format: 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.