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Title: Synthesis of Alkyl Bridged‐Tris‐α‐Amino Acids as C₃‐Symmetric and Linear Linkers
Authors: Uchino, Ayumi
Tsukano, Chihiro  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-9361-0857 (unconfirmed)
Imamoto, Tsuneo
Irie, Kazuhiro  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-7109-8568 (unconfirmed)
Author's alias: 内野, 歩美
塚野, 千尋
入江, 一浩
Keywords: Amino acids
Amyloid beta-peptides
Trimers
Issue Date: 5-Mar-2021
Publisher: Wiley
Journal title: European Journal of Organic Chemistry
Volume: 2021
Issue: 9
Start page: 1370
End page: 1377
Abstract: Although bis‐α‐amino acids have been used to synthesize dimer models of aggregative peptides involved in neurodegenerative diseases, tris‐α‐amino acids are employed to a lesser extent for trimer models. The reported tris‐α‐amino acids substituted on the 1, 3, 5‐positions of an aromatic ring are not suitable for mimicking trimers due to their low flexibility and high planarity. Here, we design and synthesize two new alkyl bridged‐tris‐α‐amino acids with Fmoc protecting groups as new flexible linkers for trimer models.
Rights: This is the peer reviewed version of the following article: A. Uchino, C. Tsukano, T. Imamoto, K. Irie, Eur. J. Org. Chem. 2021, 2021, 1370, which has been published in final form at https://doi.org/10.1002/ejoc.202001592. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
The full-text file will be made open to the public on 5 March 2022 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/261874
DOI(Published Version): 10.1002/ejoc.202001592
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