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dc.contributor.author | Nalbandian, Minas | en |
dc.contributor.author | Zhao, Mingming | en |
dc.contributor.author | Sasaki-Honda, Mitsuru | en |
dc.contributor.author | Jonouchi, Tatsuya | en |
dc.contributor.author | Lucena-Cacace, Antonio | en |
dc.contributor.author | Mizusawa, Takuma | en |
dc.contributor.author | Yasuda, Masahiko | en |
dc.contributor.author | Yoshida, Yoshinori | en |
dc.contributor.author | Hotta, Akitsu | en |
dc.contributor.author | Sakurai, Hidetoshi | en |
dc.contributor.alternative | 趙, 明明 | ja |
dc.contributor.alternative | 本田, 充 | ja |
dc.contributor.alternative | 城之内, 達也 | ja |
dc.contributor.alternative | 水澤, 卓馬 | ja |
dc.contributor.alternative | 保田, 昌彦 | ja |
dc.contributor.alternative | 吉田, 善紀 | ja |
dc.contributor.alternative | 堀田, 秋津 | ja |
dc.contributor.alternative | 櫻井, 英俊 | ja |
dc.date.accessioned | 2021-04-14T10:13:13Z | - |
dc.date.available | 2021-04-14T10:13:13Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.uri | http://hdl.handle.net/2433/262484 | - |
dc.description | 骨格筋幹細胞を純化する方法を確立 --筋肉の細胞移植治療の実現に向けて--. 京都大学プレスリリース. 2021-04-02. | ja |
dc.description | Enhanced muscle regeneration using stem cells. 京都大学プレスリリース. 2021-04-02. | en |
dc.description.abstract | The transplantation of muscle progenitor cells (MuPCs) differentiated from human induced pluripotent stem cells (hiPSCs) is a promising approach for treating skeletal muscle diseases such as Duchenne muscular dystrophy (DMD). However, proper purification of the MuPCs before transplantation is essential for clinical application. Here, by using MYF5 hiPSC reporter lines, we identified two markers for myogenic cell purification: CDH13, which purified most of the myogenic cells, and FGFR4, which purified a subset of MuPCs. Cells purified with each of the markers showed high efficiency for regeneration after transplantation and contributed to the restoration of dystrophin expression in DMD-immunodeficient model mice. Moreover, we found that MYF5 regulates CDH13 expression by binding to the promoter regions. These findings suggest that FGFR4 and CDH13 are strong candidates for the purification of hiPSC-derived MuPCs for therapeutical application. | en |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2021 The Authors. | en |
dc.rights | This is an open access article under the CC BY-NC-ND license (Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Public License). | en |
dc.subject | iPSC | en |
dc.subject | skeletal muscle | en |
dc.subject | muscle stem cell | en |
dc.subject | surface marker | en |
dc.subject | FGFR4 | en |
dc.subject | CDH13 | en |
dc.title | Characterization of hiPSC-Derived Muscle Progenitors Reveals Distinctive Markers for Myogenic Cell Purification Toward Cell Therapy | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Stem Cell Reports | en |
dc.identifier.volume | 16 | - |
dc.relation.doi | 10.1016/j.stemcr.2021.03.004 | - |
dc.textversion | publisher | - |
dc.address | Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University | en |
dc.address | Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University | en |
dc.address | Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University | en |
dc.address | Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University | en |
dc.address | Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University | en |
dc.address | Central Institute for Experimental Animals | en |
dc.address | Central Institute for Experimental Animals | en |
dc.address | Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University | en |
dc.address | Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University | en |
dc.address | Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University | en |
dc.identifier.pmid | 33798449 | - |
dc.relation.url | https://www.cira.kyoto-u.ac.jp/j/pressrelease/news/210402-010000.html | - |
dc.relation.url | https://www.cira.kyoto-u.ac.jp/e/pressrelease/news/210402-010000.html | - |
dcterms.accessRights | open access | - |
dc.identifier.pissn | 2213-6711 | - |
出現コレクション: | 学術雑誌掲載論文等 |
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