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Title: Signal Intensity and Volume of Pituitary and Thyroid Glands in Preterm and Term Infants
Authors: Otani, Sayo
Fushimi, Yasutaka  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-1982-3168 (unconfirmed)
Iwanaga, Kogoro
Tomotaki, Seiichi
Yokota, Yusuke
Oshima, Sonoko
Sakurama, Azusa
Wicaksono, Krishna Pandu
Hinoda, Takuya  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-8111-0153 (unconfirmed)
Sakata, Akihiko  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-3647-7877 (unconfirmed)
Nakajima, Satoshi  kyouindb  KAKEN_id
Okada, Tomohisa
Takita, Junko  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-2452-6520 (unconfirmed)
Kawai, Masahiko  kyouindb  KAKEN_id
Togashi, Kaori
Author's alias: 伏見, 育崇
友滝, 清一
坂田, 昭彦
中島, 諭
岡田, 知久
滝田, 順子
河井, 昌彦
Keywords: pituitary gland
thyroid gland
hypothalamic–pituitary‐thyroid axis
preterm infant
PETRA
Issue Date: Apr-2021
Publisher: Wiley
Journal title: Journal of Magnetic Resonance Imaging
Volume: 53
Issue: 4
Start page: 1151
End page: 1161
Abstract: [Background]: Hypothalamic–pituitary–thyroid (HPT) maturation has not been extensively evaluated using neonatal MRI, even though both structures are visualized on MRI. [Hypothesis]: That signal intensity and volume of pituitary and thyroid (T) glands on MRI in neonates may be interrelated. [Study Type]: Retrospective. [Subjects]: In all, 102 participants. [Field Strength/Sequence]: 3.0T, T₁‐weighted pointwise encoding time reduction with radial acquisition (PETRA).[ Assessment]: The volume of interest of the anterior pituitary (AP), posterior pituitary (PP), and T on MRI were defined on T₁‐PETRA by two radiologists, and volumes of AP (AP_vol) and thyroid (T_vol) were calculated. Gestational age (GA), chronological age (CA), GA+CA, birth weight (BW), and thyroid function were recorded. Mean and maximum signal intensities of AP, PP, and T were normalized using signals from the pons and spinal cord as follows: signal ratio of anterior pituitary/pons (AP/pons), signal ratio of posterior pituitary/pons (PP/pons), and signal ratio of thyroid/cord (T/cord) T/cord, respectively. [Statistical Tests]: Correlations between signal intensity and volume measures and GA, CA, GA+CA, and BW were assessed using Pearson's correlation coefficient or Spearman's rank correlation coefficient. Thyroid function analysis and Tmean/cord, Tmax/cord, and T_vol were evaluated using the Steel–Dwass test. Results: APmean/pons correlated positively with GA (ρ = 0.62, P < 0.001) and BW (ρ = 0.74, P < 0.001), and negatively with CA (ρ = −0.86, P < 0.001) and GA+CA (ρ = −0.46, P < 0.001). PPmean/pons correlated positively with GA (ρ = 0.49, P < 0.001) and BW (ρ = 0.63, P < 0.001), and negatively with CA (ρ = −0.70, P < 0.001) and GA+CA (r = −0.38, P < 0.001). Tmean/cord correlated positively with GA (ρ = 0.48, P < 0.001) and BW (ρ = 0.55, P < 0.001), and negatively with CA (ρ = −0.59, P < 0.001) and GA+CA (ρ = −0.22, P = 0.03). AP_vol correlated positively with GA (ρ = 0.68, P < 0.001) and BW (ρ = 0.73, P < 0.001), and negatively with CA (ρ = −0.72, P < 0.001). T_vol correlated positively with GA (ρ = 0.50, P < 0.001) and BW (ρ = 0.61, P < 0.001), and negatively with CA (ρ = −0.54, P < 0.001). APmean/pons correlated positively with Tmean/cord (ρ = 0.61, P < 0.001). [Data Conclusion]: Signal and volume of pituitary and thyroid glands correlated positively with GA and BW, and negatively with CA in neonates. [Level of Evidence]: 4 [Technical Efficacy Stage]: 5
Rights: This is the peer reviewed version of the following article: [Signal Intensity and Volume of Pituitary and Thyroid Glands in Preterm and Term Infants, JMRI, 53(4), 1151-1161], which has been published in final form at https://doi.org/10.1002/jmri.27395. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
The full-text file will be made open to the public on 16 October 2021 in accordance with publisher's 'Terms and Conditions for Self-Archiving
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/262574
DOI(Published Version): 10.1002/jmri.27395
PubMed ID: 33067897
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