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Title: Higher exercise tolerance early after allogeneic hematopoietic stem cell transplantation is the predictive marker for higher probability of later social reintegration
Authors: Hamada, Ryota
Arai, Yasuyuki  kyouindb  KAKEN_id  orcid (unconfirmed)
Kondo, Tadakazu
Harada, Kazuhiro
Murao, Masanobu
Miyasaka, Junsuke
Yoshida, Michiko
Yonezawa, Honami
Nankaku, Manabu
Ouchi, Sayako
Kitakubo, Wakako
Wadayama, Tomoko
Kanda, Junya  kyouindb  KAKEN_id  orcid (unconfirmed)
Takaori-Kondo, Akifumi
Ikeguchi, Ryosuke  kyouindb  KAKEN_id
Matsuda, Shuichi
Author's alias: 濱田, 涼太
新井, 康之
近藤, 忠一
原田, 和宏
村尾, 昌信
宮坂, 淳介
吉田, 路子
米澤, 穂波
南角, 学
大内, 紗也子
北久保, 和加子
和田山, 智子
諫田, 淳也
高折, 晃史
池口, 良輔
松田, 秀一
Keywords: Haematopoietic stem cells
Issue Date: 30-Mar-2021
Publisher: Springer Nature
Journal title: Scientific Reports
Volume: 11
Thesis number: 7190
Abstract: As the proportion of long-term survivors after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is on the rise, it is essential to consider the significance of quality of life (QOL), including reintegration with society (returning to school or work). This retrospective cohort study aims to illustrate the precise epidemiology of social reintegration later after allo-HSCT and determine its predictive indicators. We enrolled 56 patients, and 40 patients (71%) attained social reintegration at 2 years post-HSCT. Reintegration failure markedly correlated with an inferior performance status and concurrent chronic graft-versus-host disease. In non-reintegrated patients, the physical function at discharge measured by the 6-min walking distance (6MWD) was markedly decreased. On the multivariate risk analyses, sex (female; odds ratio (OR) 0.07; 95% confidence interval (CI) 0.01–0.54; p = 0.01), HCT-CI (≥ 2; OR 0.10; 95% CI 0.01–0.84; p = 0.03), and change in 6MWD (per 5% increase; OR 1.47; 95% CI 1.01–2.13; p = 0.04) were significant predictors of later social reintegration. This study suggests that a multidisciplinary strategy including rehabilitation is essential, especially in patients with poor predictive markers at an early phase, and we should consider suitable rehabilitation programs to prevent a decline in exercise tolerance and improve social reintegration and overall QOL in patients after allo-HSCT.
Description: 同種造血幹細胞移植後における社会復帰の予測因子を発見 --移植後リハビリテーションがもつ重要性--. 京都大学プレスリリース. 2021-04-09.
Rights: © The Author(s) 2021
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
DOI(Published Version): 10.1038/s41598-021-86744-8
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