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Title: Lowered sensitivity of bitter taste receptors to β-glucosides in bamboo lemurs: an instance of parallel and adaptive functional decline in TAS2R16?
Authors: Itoigawa, Akihiro
Fierro, Fabrizio
Chaney, E, Morgan
Lauterbur, Elise, M
Hayakawa, Takashi
Tosi, J, Anthony
Niv, Y, Masha
Imai, Hiroo
Author's alias: 糸井川, 壮大
早川, 卓志
今井, 啓雄
Keywords: bitter taste receptor
molecular adaptation
Issue Date: Apr-2021
Publisher: Royal Society
Journal title: Proceedings of the Royal Society B: Biological Sciences
Volume: 288
Issue: 1948
Thesis number: 20210346
Abstract: Bitter taste facilitates the detection of potentially harmful substances and is perceived via bitter taste receptors (TAS2Rs) expressed on the tongue and oral cavity in vertebrates. In primates, TAS2R16 specifically recognizes β-glucosides, which are important in cyanogenic plants' use of cyanide as a feeding deterrent. In this study, we performed cell-based functional assays for investigating the sensitivity of TAS2R16 to β-glucosides in three species of bamboo lemurs (Prolemur simus, Hapalemur aureus and H. griseus), which primarily consume high-cyanide bamboo. TAS2R16 receptors from bamboo lemurs had lower sensitivity to β-glucosides, including cyanogenic glucosides, than that of the closely related ring-tailed lemur (Lemur catta). Ancestral reconstructions of TAS2R16 for the bamboo-lemur last common ancestor (LCA) and that of the Hapalemur LCA showed an intermediate sensitivity to β-glucosides between that of the ring-tailed lemurs and bamboo lemurs. Mutagenetic analyses revealed that P. simus and H. griseus had separate species-specific substitutions that led to reduced sensitivity. These results indicate that low sensitivity to β-glucosides at the cellular level-a potentially adaptive trait for feeding on cyanogenic bamboo-evolved independently after the Prolemur-Hapalemur split in each species.
Description: 竹食サル類の苦味感覚の進化を解明 --竹が先か苦味が先か--. 京都大学プレスリリース. 2021-04-16.
Rights: © 2021 The Authors.
Published by the Royal Society under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, provided the original author and source are credited.
DOI(Published Version): 10.1098/rspb.2021.0346
PubMed ID: 33849315
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